期刊
APPLIED SCIENCES-BASEL
卷 11, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/app11219933
关键词
asthma; chronic obstructive pulmonary disease; COPD; epithelial-mesenchymal trophic unit; muco-microbiotic layer; nanovesicles; exosomes; outer membrane vesicles; microbiota
EMTU and MML play crucial roles in maintaining airway homeostasis and the pathogenesis of airway diseases, with nanovesicles produced by them potentially serving as key communication tools among different cell types.
The epithelial-mesenchymal trophic unit (EMTU) is a morphofunctional entity involved in the maintenance of the homeostasis of airways as well as in the pathogenesis of several diseases, including asthma and chronic obstructive pulmonary disease (COPD). The muco-microbiotic layer (MML) is the innermost layer of airways made by microbiota elements (bacteria, viruses, archaea and fungi) and the surrounding mucous matrix. The MML homeostasis is also crucial for maintaining the healthy status of organs and its alteration is at the basis of airway disorders. Nanovesicles produced by EMTU and MML elements are probably the most important tool of communication among the different cell types, including inflammatory ones. How nanovesicles produced by EMTU and MML may affect the airway integrity, leading to the onset of asthma and COPD, as well as their putative use in therapy will be discussed here.
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