期刊
APPLIED SCIENCES-BASEL
卷 12, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/app12010428
关键词
glucose isomerase; xylose isomerase; high-fructose corn syrup; HFCS; bioethanol; structure
类别
资金
- National Research Foundation of Korea (NRF) [NRF-2017R1D1A1B03033087, NRF-2017M3A9F6029736, NRF-2021R1I1A1A01050838]
- Korea Initiative for Fostering University of Research and Innovation (KIURI) Program of the NRF [NRF-2020M3H1A1075314]
Glucose isomerase plays a crucial role in sugar metabolism and industrial applications, including the production of high-fructose corn syrup and bioethanol. This review presents an overview of the functions, structure, and applications of glucose isomerase, as well as recent advancements in its characterization and engineering.
Glucose isomerase (GI, also known as xylose isomerase) reversibly isomerizes D-glucose and D-xylose to D-fructose and D-xylulose, respectively. GI plays an important role in sugar metabolism, fulfilling nutritional requirements in bacteria. In addition, GI is an important industrial enzyme for the production of high-fructose corn syrup and bioethanol. This review introduces the functions, structure, and applications of GI, in addition to presenting updated information on the characteristics of newly discovered GIs and structural information regarding the metal-binding active site of GI and its interaction with the inhibitor xylitol. This review provides an overview of recent advancements in the characterization and engineering of GI, as well as its industrial applications, and will help to guide future research in this field.
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