The Emerging Role of Cyclodextrin Metal-Organic Frameworks in Ostheotherapeutics

Metal-Organic Frameworks (MOFs) are a class of coordination compounds with high versatility of design and a high loading ability. These properties have made them increasingly attractive for drug delivery, with research focusing mostly on the preparation of biocompatible MOFs. A suitable strategy is the use of cyclodextrins, cyclic oligosaccharides with excellent biosafety profiles. This review summarises the early steps taken in the application of cyclodextrin-coated and cyclodextrin-based MOFs in the treatment of bone-related diseases divided into three categories: cyclodextrin-coated MOFs, cyclodextrin-based MOFs and cross-linked derivatives of CD-MOFs. Applications in the delivery of bisphosphonates, osteoporotic regulating drugs and non-steroidal anti-inflammatory drugs, for osteoarthritis management, are highlighted. Lastly, the use of these materials in dentistry is exemplified with a recent report.

Automated summary

Metal-Organic Frameworks (MOFs), as a class of coordination compounds, have high versatility and loading ability, making them attractive for drug delivery. This review summarizes the early use of cyclodextrin-coated and cyclodextrin-based MOFs in the treatment of bone-related diseases, including cyclodextrin-coated MOFs, cyclodextrin-based MOFs, and cross-linked derivatives of CD-MOFs. The review highlights their applications in delivering bisphosphonates, osteoporotic regulating drugs, and non-steroidal anti-inflammatory drugs for osteoarthritis management, as well as their recent use in dentistry.