4.6 Article

Response of Sex Steroid Hormone Synthesis Substrates in Serum and Testes of Male Tilapia (Oreochromis niloticus) Exposed to Methomyl and Its Recovery Pattern

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APPLIED SCIENCES-BASEL
卷 11, 期 22, 页码 -

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MDPI
DOI: 10.3390/app112210997

关键词

pesticide; freshwater fish; cholesterol; pregnenolone; progesterone; depuration period

资金

  1. China Agriculture Research System of MOF [CARS-46]
  2. National Key Research and Development Program of China [2020YFD0900502]

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The study found that low concentrations of methomyl did not significantly affect the sex steroid hormone levels in male tilapia, with 2 μg/L identified as a preliminary threshold for non-effective doses. However, high concentrations of methomyl significantly inhibited sex steroid hormone levels and caused irreversible damage when equal to or greater than 200 μg/L, indicating a dose-dependent relationship.
The response of synthetic substrates of sex steroid hormones-cholesterol (CHO), pregnenolone (PREG), and progesterone (PROG)-in the serum and testes of male tilapia (Oreochromis niloticus) to the environmental estrogen pesticide methomyl (0.2, 2, 20, and 200 mu g & BULL;L-1) was evaluated using static-water contact toxicity tests. The results showed that low methomyl concentrations (0.2 and 2 mu g & BULL;L-1) had no significant effects on the contents of CHO, PREG, and PROG in the serum and testes of male tilapia (p > 0.05). Consequently, the concentration of 2 mu g & BULL;L-1 could be used as a preliminary reference threshold for the non-effective dose of methomyl in male tilapia. Exposure to high methomyl concentrations (20 and 200 mu g & BULL;L-1) significantly inhibited the levels of CHO, PREG, and PROG in the serum and testes of male tilapia (p < 0.05) and showed a dose-response relationship. Sex steroid hormone synthesis substrate damage to male tilapia caused by less than 20 mu g & BULL;L-1 methomyl was reversible, while the damage caused by equal to or greater than 200 mu g & BULL;L-1 methomyl was irreversible when tilapia were transferred to methomyl-free water for 18 days. Thus, a concentration of 200 mu g & BULL;L-1 could be used as a reference threshold for irreversible damage caused by methomyl in male tilapia.

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