期刊
ADVANCED SCIENCE
卷 9, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/advs.202104125
关键词
large solid tumor therapy; polymer nanoparticles; sonodynamic therapy; tumor hypoxia; tumor penetration
资金
- National Key R&D Program of China [2017YFA0701301, 2017YFA0205400]
- National Natural Science Foundation of China [92163214, 51690153, 21720102005, 51903120]
- Fundamental Research Funds for the Central Universities [020514913212]
- Natural Science Foundation of Jiangsu Province [BK20202002]
Sonodynamic therapy (SDT) shows promise in treating large solid tumors, but its efficacy is often compromised by the poor penetration and hypoxia in the tumor environment. This study reports the use of a semiconducting polymer nanoparticle (SPNC) to enhance tumor penetration and alleviate tumor hypoxia in sonodynamic therapy of large solid tumors.
Sonodynamic therapy (SDT) holds growing promise in deep-seated or large solid tumor treatment owing to its high tissue penetration depth ability; however, its therapeutic efficacy is often compromised due to the hypopermeable and hypoxic characteristics in the tumor milieu. Herein, a semiconducting polymer nanoparticle (SPNC) that synergistically enhances tumor penetration and alleviates tumor hypoxia is reported for sonodynamic therapy of large solid tumors. SPNC comprises a semiconducting polymer nanoparticle core as a sonodynamic converter coated with a poly (ethylene glycol) corona. An oxygen-modulating enzyme, catalase, is efficiently conjugated to the surface of nanoparticles via the coupling reaction. Superior to its counterpart SPNCs (SPNC2 (84 nm) and SPNC3 (134 nm)), SPNC with the smallest size (SPNC1 (35 nm)) can efficiently penetrate throughout the tumor interstitium to alleviate whole tumor hypoxia in a large solid tumor model. Upon ultrasound (US) irradiation, SPNC1 can remotely generate sufficient singlet oxygen to eradicate tumor cells at a deep-tissue depth. Such a single treatment of SPNC1-medicated sonodynamic therapy effectively inhibits tumor growth in a large solid tumor mouse model. Therefore, this study provides a generalized strategy to synergistically overcome both poor penetration and hypoxia of large tumors for enhanced cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据