期刊
ADVANCED SCIENCE
卷 9, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/advs.202104629
关键词
light-emitting diodes; photobiomodulation; poststroke cognitive impairments; stroke
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF-2019R1A2C1088796, NRF2021M3A9E4081781, NRF-2021R1A5A1032937]
Photobiomodulation (PBM) has the potential to improve tissue function and enhance regeneration in stroke. A miniaturized electronic device system with light-emitting diodes (LEDs) has been developed for in vivo brain PBM in mice. The PBM with a 630 nm LED array has been proven to be the most effective for reducing infarction volume and neurological impairment after ischemic stroke.
Photobiomodulation (PBM) has received attention due to its potential for improving tissue function and enhancing regeneration in stroke. A lightweight, compact, and simple system of miniaturized electronic devices consisting of packaged light-emitting diodes (LEDs) that incorporates a flexible substrate for in vivo brain PBM in a mouse model is developed. Using this device platform, the preventive and therapeutic effects of PBM affixed to the exposed skull of mice in the photothrombosis and middle cerebral artery occlusion stroke model are evaluated. Among the wavelength range of 630, 850, and 940 nm LED array, the PBM with 630-nm LED array is proved to be the most effective for reducing the infarction volume and neurological impairment after ischemic stroke. Moreover, the PBM with 630 nm LED array remarkably improves the capability of spatial learning and memory in the chronic poststroke phase, attenuates AIM2 inflammasome activation and inflammasome-mediated pyroptosis, and modulates microglial polarization in the hippocampus and cortex 7 days following ischemic stroke. Thus, PBM may prevent tissue and functional damage in acute ischemic injury, thereby attenuating the development of cognitive impairment after stroke.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据