期刊
ADVANCED SCIENCE
卷 8, 期 24, 页码 -出版社
WILEY
DOI: 10.1002/advs.202102545
关键词
antibacterial hydrogels; hydrogel microspheres; living bacteria; microbial competition; wound healing
资金
- Outstanding academic leaders plan of Shanghai [2018BR07]
- Shanghai Sailing Program [21YF1434900]
- Climbing Talent Program of Shanghai Tenth People's Hospital [2021SYPDRC009]
A bio-bacterial hydrogel scaffold has been reported to accelerate the healing of infected wounds by using beneficial bacteria that secrete antibacterial substances. The hydrogel protects bacteria from immune system attack and prevents them from escaping, promoting wound closure and tissue regeneration. This work may offer new avenues for the clinical application of living bacteria in managing infected wounds.
Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds and even serious tissue damage. Traditional treatments can not only kill pathogenic bacteria, but also suppress the growth of beneficial bacteria, thus destroying the balance of the damaged skin microbial ecosystem. Here, a living bacterial hydrogel scaffold is reported that accelerates infected wound healing through beneficial bacteria secreting antibacterial substances. Lactobacillus reuteri, a common probiotic, is encapsulated in hydrogel microspheres by emulsion polymerization and further immobilized in a hydrogel network by covalent cross-linking of methacrylate-modified hyaluronic acid. Owing to light-initiated crosslinking, the hydrogel dressing can be generated in situ at the wound site. This hydrogel scaffold not only protects bacteria from immune system attack, but also prevents bacteria from escaping into the local environment, thus avoiding potential threats. Both in vitro and in vivo experiments show that it has excellent ability against harmful bacteria and anti-inflammatory capabilities, promoting infected wound closure and new tissue regeneration. This work may open up new avenues for the application of living bacteria in the clinical management of infected wounds.
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