4.8 Article

Supramolecular Radiosensitizer Based on Hypoxia-Responsive Macrocycle

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

A hypoxia-responsive supramolecular formulation for imaging-guided photothermal therapy

Tian-Xing Zhang et al.

Summary: This study presents a novel supramolecular photothermal agent (PTA) prepared using a stimuli-responsive macrocyclic host, which overcomes the challenges of hydrophobicity, photodegradation, and low signal-to-noise ratio faced by organic small-molecule PTAs. The supramolecular PTA demonstrates enhanced solubility, photostability, and photothermal conversion, and exhibits promising imaging-guided photothermal therapy efficacy both in vitro and in vivo.

THERANOSTICS (2022)

Review Chemistry, Multidisciplinary

Biomedical Applications of Calixarenes: State of the Art and Perspectives

Yu-Chen Pan et al.

Summary: Calixarenes and their derivatives, as versatile supramolecular hosts, have extensive biomedical applications in biosensing, bioimaging, and therapy, showing great potential as therapeutic agents.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Andrology

miRNAs and radiotherapy response in prostate cancer

Maria Yu Konoshenko et al.

Summary: This study analyzed the impact of radiotherapy on miRNA expression in prostate cancer and identified potential markers for therapeutic effectiveness through meta-analysis and data cross-analysis. The selected miRNA and gene panels have the potential to serve as prognostic and radiotherapy effectiveness markers not only for PCa but also for other types of cancer.

ANDROLOGY (2021)

Article Chemistry, Multidisciplinary

Bioorthogonal Coordination Polymer Nanoparticles with Aggregation-Induced Emission for Deep Tumor-Penetrating Radio- and Radiodynamic Therapy

Jingjing Liu et al.

Summary: Radiodynamic therapy (RDT) is a promising therapeutic approach for cancer treatment that combines ionizing irradiation and localized photodynamic therapy (PDT). Hf-AIE coordination polymer nanoparticles (CPNs) show strong RT and RDT effects under X-ray irradiation. Bioorthogonal click chemistry enhances tumor accumulation and retention of CPNs, leading to significant killing of cancer cells without noticeable biotoxicity.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for Cancer Immunotherapy

Yu Zhang et al.

Summary: A programmable immune activation nanomedicine (PIAN) is reported in this study, which sequentially finishes multiple steps after intravenous injection and elicits robust antitumor immunity in situ. This innovative approach provides a new framework for designing programmable nanomedicine as an in situ cancer vaccine for cancer immunotherapy.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

Macrocyclic-Amphiphile-Based Self-Assembled Nanoparticles for Ratiometric Delivery of Therapeutic Combinations to Tumors

Zhanzhan Zhang et al.

Summary: Combination chemotherapy involves using multiple drugs to treat cancer, and precise drug loading and ratiometric delivery are essential for achieving optimal therapeutic effects. The MASN nanoparticle system integrates multiple macrocyclic cavities to achieve precise drug loading and ratio-controlled delivery, ensuring efficient drug release upon reaching tumor tissues.

ADVANCED MATERIALS (2021)

Article Chemistry, Multidisciplinary

In Situ Supramolecular Self-Assembly of Pt(IV) Prodrug to Conquer Cisplatin Resistance

Qian Wang et al.

Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

Review Chemistry, Multidisciplinary

Pillararene-based supramolecular systems for theranostics and bioapplications

Huangtianzhi Zhu et al.

Summary: Pillararenes and their derivatives are important macrocycles in supramolecular chemistry, widely studied and applied in various fields, especially in biological and medical areas. They can be used to construct functional biomaterials, increase water solubility and biocompatibility of drugs, and modify solid materials to enhance their functions and controllability. The review summarizes recent efforts on pillararene-based supramolecular systems with theranostics and other biological applications, outlining design principles, preparation strategies, identifications and bio-applications, as well as future challenges and directions in the field.

SCIENCE CHINA-CHEMISTRY (2021)

Article Chemistry, Multidisciplinary

Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

Kuikun Yang et al.

Summary: A supramolecular nanoparticle has been developed for chemodynamic therapy, which can release radicals and platinum (IV) prodrug in tumors to enhance H2O2 generation. The nanoparticles can be readily excreted via renal clearance to avoid systemic toxicity, providing potential for novel cascade chemo/chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Review Nanoscience & Nanotechnology

Plasmonic gold nanoagents for cancer imaging and therapy

Qinrui Fu et al.

Summary: Gold nanoparticles (AuNPs) have excellent biocompatibility and unique physical and chemical properties, making them suitable for cancer imaging, photothermal therapy, radiotherapy, photodynamic therapy, and chemotherapy. They provide a new idea for simultaneous cancer diagnosis and treatment.
Review Nanoscience & Nanotechnology

Nanomaterials for cascade promoted catalytic cancer therapy

Zongrui Tong et al.

Summary: Catalytic therapy using special substances at tumor sites is a promising approach to achieve tumor-specific treatment or enhance the efficacy of other treatments. Utilizing nanomaterials and cascade strategies can significantly improve the effectiveness of catalytic therapy, presenting important implications for cancer treatment.
Review Chemistry, Multidisciplinary

Nanomaterials for Combinational Radio-Immuno Oncotherapy

Juan Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Article Chemistry, Multidisciplinary

A General Hypoxia-Responsive Molecular Container for Tumor-Targeted Therapy

Tian-Xing Zhang et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

A host-guest drug delivery nanosystem for supramolecular chemotherapy

Xin-Yue Hu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Article Nanoscience & Nanotechnology

Pillar[5]arene-Based Switched Supramolecular Photosensitizer for Self-Amplified and pH-Activated Photodynamic Therapy

Baoxuan Huang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

Article Materials Science, Multidisciplinary

Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery

Cheng Gao et al.

MATERIALS TODAY (2020)

Article Chemistry, Multidisciplinary

Supramolecular Induction of Mitochondrial Aggregation and Fusion

Chen Sun et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Review Chemistry, Multidisciplinary

Supramolecular prodrugs based on host-guest interactions

Wen-Chao Geng et al.

CHEMICAL SOCIETY REVIEWS (2020)

Article Chemistry, Multidisciplinary

Cancer Therapy by Targeting Thioredoxin Reductase Based on Selenium-Containing Dynamic Covalent Bond

Shuojiong Pan et al.

CCS CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Emerging Strategies of Nanomaterial-Mediated Tumor Radiosensitization

Jiani Xie et al.

ADVANCED MATERIALS (2019)

Review Chemistry, Multidisciplinary

Macrocyclic Amphiphiles for Drug Delivery

Zhe Zheng et al.

ISRAEL JOURNAL OF CHEMISTRY (2019)

Review Oncology

Peptide Receptor Radiotherapy: Current Approaches and Future Directions

Grace Kong et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2019)

Article Chemistry, Multidisciplinary

A Noncovalent Fluorescence Turn-on Strategy for Hypoxia Imaging

Wen-Chao Geng et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Multidisciplinary

Hypoxia-targeted drug delivery

Amit Sharma et al.

CHEMICAL SOCIETY REVIEWS (2019)

Review Medicine, Research & Experimental

Gene delivery based on macrocyclic amphiphiles

Wen-Chao Geng et al.

THERANOSTICS (2019)

Article Materials Science, Biomaterials

Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy

Xiaoqiu Li et al.

BIOMATERIALS SCIENCE (2019)

Review Chemistry, Multidisciplinary

Pillararene-based self-assembled amphiphiles

Huacheng Zhang et al.

CHEMICAL SOCIETY REVIEWS (2018)

Article Chemistry, Multidisciplinary

Biomarker Displacement Activation: A General Host-Guest Strategy for Targeted Phototheranostics in Vivo

Jie Gao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Review Pharmacology & Pharmacy

Cancer Radiosensitizers

Hao Wang et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2018)

Review Chemistry, Multidisciplinary

Drug delivery by supramolecular design

Matthew J. Webber et al.

CHEMICAL SOCIETY REVIEWS (2017)

Article Chemistry, Multidisciplinary

BSA-Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy

Yong Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2016)

Review Oncology

Clinical development of new drug-radiotherapy combinations

Ricky A. Sharma et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Review Chemistry, Multidisciplinary

Cucurbituril-Based Molecular Recognition

Steven J. Barrow et al.

CHEMICAL REVIEWS (2015)

Article Chemistry, Multidisciplinary

H2O2-Activatable and O2-Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells

Huachao Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Oncology

Opportunities and challenges of radiotherapy for treating cancer

Doerthe Schaue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Review Chemistry, Multidisciplinary

Biological applications of functionalized calixarenes

Satish Balasaheb Nimse et al.

CHEMICAL SOCIETY REVIEWS (2013)

Review Oncology

Past, present, and future of radiotherapy for the benefit of patients

Juliette Thariat et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2013)

Review Multidisciplinary Sciences

The DNA damage response and cancer therapy

Christopher J. Lord et al.

NATURE (2012)

Review Chemistry, Multidisciplinary

Cyclodextrin-based gene delivery systems

Carmen Ortiz Mellet et al.

CHEMICAL SOCIETY REVIEWS (2011)

Review Chemistry, Multidisciplinary

The Potential of Cucurbit[n]urils in Drug Delivery

Shonagh Walker et al.

ISRAEL JOURNAL OF CHEMISTRY (2011)

Review Pharmacology & Pharmacy

Cyclodextrins as pharmaccutical solubilizers

Marcus E. Brewster et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

Review Oncology

Exploiting tumour hypoxia in cancer treatment

JM Brown et al.

NATURE REVIEWS CANCER (2004)