期刊
ADVANCED SCIENCE
卷 9, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/advs.202105466
关键词
discography contrast agent; intervertebral disc degeneration; mitochondrial structure; Prussian blue nanoparticles; reactive oxygen species; superoxide dismutase 1; ubiquitin-proteasome degradation
资金
- National Natural Science Foundation of China [81871790, 81801821]
- National Key R&D Program of China [2017YFB1104104]
- Shanghai Leading Talents Program in 2020 [110]
- Shanghai Frontiers Science Center of Degeneration and Regeneration in Skeletal System
The study found that Prussian blue nanoparticles (PBNPs) can alleviate intracellular oxidative stress and increase the activity of antioxidant enzymes, thus improving mitochondrial structure to enhance antioxidation ability and rescuing disc degeneration caused by oxidative stress in a rat model.
Discography often destroys the hypoxic environment in the intervertebral disc and accelerates intervertebral disc degeneration (IVDD). Therefore, it often fails to meet the requirements for application in clinical practice. This technology mainly increases the reactive oxygen species (ROS) in the IVD. As so, it is particularly critical to develop strategies to avoid this degeneration mechanism. Prussian blue nanoparticles (PBNPs) are found to enhance development under magnetic resonance T1 and have antioxidant enzyme activity. The key results of the present study confirm that PBNPs alleviate intracellular oxidative stress and increase the intracellular activities of antioxidant enzymes, such as superoxide dismutase 1 (SOD1). PBNPs can rescue nucleus pulposus cell degeneration by increasing oxidoreductase system-related mRNA and proteins, especially by stabilizing SOD1 from ubiquitination-proteasome degradation, thus improving the mitochondrial structure to increase antioxidation ability, and finally rescuing ROS-induced IVDD in a rat model. Therefore, it is considered that PBNPs can be a potential antioxidation-protective discography contrast agent.
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