期刊
ADVANCED SCIENCE
卷 8, 期 24, 页码 -出版社
WILEY
DOI: 10.1002/advs.202100808
关键词
adipogenesis; autonomic nervous system; bone marrow mesenchymal stem; stromal cells; neuropeptide Y; osteocyte; osteogenesis
资金
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019-RC-HL-024]
- Innovation Driven Project of Central South University [2019CX014, 2018CX029]
- National Natural Science Foundation of China [81670807, 81871822, 81522012, 82072504, 81702237, 81701383, 81801395, 81974127, 81600699]
- Science and Technology Innovation Program of Hunan Province [2020RC4008]
- Science and Technology Plan Project of Hunan Province [2017XK2039, 2018RS3029]
- Hunan Province Natural Science Foundation of China [2020JJ5883, 2020JJ5900, 2020JJ4914]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2018B045, CX20190148]
- Special Funding for the Construction of Innovative Provinces in Hunan [2019SK2301, 2020SK3002]
- Fundamental Research Funds for the Central Universities of Central South University [2017zzts211, 2019zzts804, 2018zzts895]
- Free Exploration Program of Central South University [502221901]
- China Postdoctoral Science Foundation [2017M612596, 2018M632998, 2019T120717, 2020T130142ZX]
This study reveals that osteocytes regulate the differentiation of BMSCs into osteoblasts or adipocytes by secreting neuropeptide Y (NPY), with increased NPY expression associated with aging and osteoporosis. Deletion of NPY in osteocytes leads to high bone mass phenotype and attenuated bone-fat imbalance. The study suggests a new mode of neuronal control of bone metabolism through ANS-induced regulation of osteocyte NPY.
A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age- and menopause-associated bone loss and marrow adiposity. Here it is found that osteocytes, the most abundant bone cells, promote adipogenesis and inhibit osteogenesis of BMSCs by secreting neuropeptide Y (NPY), whose expression increases with aging and osteoporosis. Deletion of NPY in osteocytes generates a high bone mass phenotype, and attenuates aging- and ovariectomy (OVX)-induced bone-fat imbalance in mice. Osteocyte NPY production is under the control of autonomic nervous system (ANS) and osteocyte NPY deletion blocks the ANS-induced regulation of BMSC fate and bone-fat balance. gamma-Oryzanol, a clinically used ANS regulator, significantly increases bone formation and reverses aging- and OVX-induced osteocyte NPY overproduction and marrow adiposity in control mice, but not in mice lacking osteocyte NPY. The study suggests a new mode of neuronal control of bone metabolism through the ANS-induced regulation of osteocyte NPY.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据