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Review
Biochemical Research Methods
The crystal structures of the enzyme hydroxymethylbilane synthase, also known as porphobilinogen deaminase
John R. Helliwell
Summary: This article surveys thirty years of crystal structures of the enzyme hydroxymethylbilane synthase, aiming to elucidate the structural basis of its complex reaction mechanism, and evaluates the consistency between the structures as well as the precision of the molecular models. It also discusses the use of 3D structural techniques and future research directions, including determining the protonation states of key amino-acid residues and exploring the molecular engine behind the complex reaction.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2021)
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