期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 8, 期 2, 页码 620-625出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c01004
关键词
strontium coating; bone formation; implant; osseointegration; X-ray fluorescence; synchrotron
资金
- Innovation Fund Denmark through the project Strontium functionalized titanium implants
- Danish Agency for Science, Technology, and Innovation
- Sino-Danish Center for Education and Research
- project CALIPSOplus from the EU Framework Programme for Research and Innovation HORIZON 2020 [730872]
It has been found that a local, sustained release of Sr from Ti-Sr-O coatings significantly increases the Sr/Ca ratio in periimplant bone.
It is well known that strontium (Sr) has a significant effect on periimplant bone healing when administered systemically. Due to the risk of adverse effects of such treatments, new routes focusing on the local, sustained release of Sr from bone- implant contact surfaces have been explored, with success in in vivo experiments. However, the increase of Sr concentrations in the peri-implant bone has not been described in depth yet. Here, we show that a local, sustained Sr release from Ti-Sr-O physical vapor deposition (PVD) coatings by magnetron sputter coating increases the Sr/Ca ratio close to the implant in a rabbit model and that the Sr/Ca background level is reached approximately 500 mu m from the implant.
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