期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 11, 页码 5118-5128出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00575
关键词
biofilm; graphene oxide; aptamer; photothermal therapy; photodynamic therapy
资金
- National Natural Science Foundation of China [31770109, 21775036]
- Changsha Municipal Natural Science Foundation [kq2014181]
The researchers developed a novel intelligent phototherapeutic nanoplatform for targeted treatment and controlled release in Salmonella Typhimurium biofilm therapy. The nano-sheets conjugated with aptamers can specifically accumulate near abscess caused by pathogens, enhancing local drug concentration and promoting precise delivery.
Bacterial biofilms are usually resistant to antibiotics, thus powerful methods are required for removal. Nanomaterial involving a combination of treatment modalities recently has been recognized as an effective alternative to combat biofilm. However, its targeted and controlled release in bacterial infection is still a major challenge. Here, we present an intelligent phototherapeutic nanoplatform consisting of an aptamer (Apt), indocyanine green (ICG), and carboxyl-functionalized graphene oxide (GO-COOH), namely, ICG@GO-Apt, for targeted treatment of the biofilm formed by Salmonella Typhimurium. Since Aptconjugated nanosheets (NSs) can specifically accumulate near abscess caused by the pathogens, they enhance greatly the local drug molecule concentration and promote their precise delivery. They can simultaneously generate heat and reactive oxygen species under near-infrared irradiation for photothermal/photodynamic therapy, thereby significantly enhancing biofilm elimination. The phototherapeutic ICG@GO-Apt also displays a good biocompatibility. More importantly, the multifunction phototherapeutic platform shows an efficient biofilm elimination with an efficiency of greater than 99.99% in an abscess formation model. Therefore, ICG@GO-Apt NSs with bacteria-targeting capability provide a reliable tool for clinical bacterial infection that circumvents antibiotic resistance.
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