期刊
NEUROIMAGE-CLINICAL
卷 33, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nicl.2021.102916
关键词
Rumination; Metastability; White matter integrity; Resting-state fMRI; Diffusion tensor imaging; Major depressive disorder
类别
资金
- Key-Area Research and Development Program of Guangdong Province [2018B30334001]
- University of Hong Kong May Endowed Professorship in Neuropsychology
- National Natural Science Foundation of China [NSFC: 31900806]
- Science and Technology Program of Guangzhou, China [202007030012]
This study investigated the relationship between white matter connectivity and the temporal dynamics of functional connectivity in rumination. Results showed that lower global metastability and higher global synchrony of dynamic functional connectivity were associated with higher levels of rumination, and these variables mediated the connection between white matter integrity and rumination.
Rumination is a repetitive and compulsive thinking focusing on oneself, and the nature and consequences of distress. It is a core characteristic in psychiatric disorders characterized by affective dysregulation, and emerging evidence suggests that rumination is associated with aberrant dynamic functional connectivity and structural connectivity. However, the underlying neural mechanisms remain poorly understood. Here, we adopted a multimodal approach and tested the hypothesis that white matter connectivity forms the basis of the implications of temporal dynamics of functional connectivity in the rumination trait. Fifty-three depressed and ruminative individuals and a control group of 47 age- and gender-matched individuals with low levels of rumination underwent resting-state fMRI and diffusion tensor imaging. We found that lower global metastability and higher global synchrony of the dynamic functional connectivity were associated with higher levels of rumination. Specifically, the altered global synchrony and global metastability mediated the association between white matter integrity of the genu of the corpus callosum to rumination. Hence, our findings offered the first line of evidence for the intricate role of (sub)optimal transition of functional brain states in the connection of structural brain connectivity in ruminative thinking.
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