期刊
NANOMATERIALS
卷 11, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nano11112796
关键词
ligament; biomedical applications; composites; 3D-printed scaffold; textile-engineered scaffold; functionalized graphene; PLA
类别
资金
- FCT through the National Funds [UIDB/05256/2020, UIDP/05256/2020]
- FCT and European Program FEDER/COMPETE through the project [PTDC/BTM-MAT/28123/2017]
- FCT, European Union and European Social Fund (FSE) through the PhD Grant [SFRH/BD/138244/2018]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/138244/2018, PTDC/BTM-MAT/28123/2017] Funding Source: FCT
The ACL is prone to injury and often requires surgery due to poor regenerative capacity. Current TE strategies are based on fiber scaffolds. Composite filaments based on PLA and reinforced with graphite nanoplatelets were successfully produced and showed potential for ligament TE applications.
The anterior cruciate ligament (ACL) is one of the most prone to injury in the human body. Due to its insufficient vascularization and low regenerative capacity, surgery is often required when it is ruptured. Most of the current tissue engineering (TE) strategies are based on scaffolds produced with fibers due to the natural ligament's fibrous structure. In the present work, composite filaments based on poly(L-lactic acid) (PLA) reinforced with graphite nanoplatelets (PLA+EG) as received, chemically functionalized (PLA+f-EG), or functionalized and decorated with silver nanoparticles [PLA+((f-EG)+Ag)] were produced by melt mixing, ensuring good filler dispersion. These filaments were produced with diameters of 0.25 mm and 1.75 mm for textile-engineered and 3D-printed ligament scaffolds, respectively. The resulting composite filaments are thermally stable, and the incorporation of graphite increases the stiffness of the composites and decreases the electrical resistivity, as compared to PLA. None of the filaments suffered significant degradation after 27 days. The composite filaments were processed into 3D scaffolds with finely controlled dimensions and porosity by textile-engineered and additive fabrication techniques, demonstrating their potential for ligament TE applications.
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