☆ 4.7 Review

Applications of Chitosan-Alginate-Based Nanoparticles-An Up-to-Date Review

NANOMATERIALS (2022)

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Article Nanoscience & Nanotechnology

Fabrication of chitosan-alginate nanospheres for controlled release of cartap hydrochloride

Ishtpreet Kaur et al.

Summary: In this study, insecticide cartap hydrochloride was fabricated as nanospheres using a two-step method. The nanospheres showed good stability and encapsulation efficiency. The release experiments indicated that the nanospheres had controlled release properties.

NANOTECHNOLOGY (2022)

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Article Chemistry, Applied

Chitosan oligosaccharide/alginate nanoparticles as an effective carrier for astaxanthin with improving stability, in vitro oral bioaccessibility, and bioavailability

Feuangthit Niyamissara Sorasitthiyanukarn et al.

Summary: In this study, ATX-loaded chitosan oligosaccharide/alginate nanoparticles (ATX-COANPs) were successfully fabricated with optimized conditions. These nanoparticles exhibited good stability and sustained release characteristics under various conditions. Encapsulation within COANPs led to increased in vitro bioaccessibility, bioavailability, and antioxidant activity of ATX, suggesting potential applications in developing an effective oral delivery system for nutraceuticals or functional foods.

FOOD HYDROCOLLOIDS (2022)

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Review Chemistry, Multidisciplinary

Functionalization of polymers and nanomaterials for water treatment, food packaging, textile and biomedical applications: a review

Pooyan Makvandi et al.

Summary: The inert nature of most commercial polymers and nanomaterials limits their applications in various industrial fields, which can be solved by surface modifications to improve physicochemical and biological properties. Polymer functionalization allows for specific moieties and conjugate molecules to be grafted onto surfaces, enhancing material performances. Further research is needed on cell-polymer interactions, nanosafety, and industrial scale manufacturing to fully understand the advantages and challenges of polymer functionalization.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

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Review Chemistry, Applied

Chitosan-based nanoparticles against bacterial infections

Somaye Rashki et al.

Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Applied

Starch, cellulose, pectin, gum, alginate, chitin and chitosan derived (nano) materials for sustainable water treatment: A review

Mahmoud Nasrollahzadeh et al.

Summary: Natural biopolymers, such as cellulose, chitin/chitosan, and starch, are considered greener, sustainable, and eco-friendly materials due to their outstanding structural features, abundant availability, nontoxicity, and biocompatibility. In recent years, polysaccharides have been widely used for making various catalysts, with polysaccharides-supported metal/metal oxide materials being an effective strategy in nanotechnology. Polysaccharides adorned with nanomaterials have shown promising potential as efficient catalysts or sorbents in removing a variety of aqueous pollutants and contaminants.

CARBOHYDRATE POLYMERS (2021)

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Article Chemistry, Applied

Effect of interfacial layer number on the storage stability and in vitro digestion of fish oil-loaded multilayer emulsions consisting of gelatin particle and polysaccharides

Mengzhen Ding et al.

Summary: The study found that the number of interfacial layers in multilayer emulsions affects storage stability and emulsion stability during digestion, but has no impact on droplet coalescence and stability during small intestinal phase digestion.

FOOD CHEMISTRY (2021)

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Review Food Science & Technology

Alginate-based delivery systems for food bioactive ingredients: An overview of recent advances and future trends

Duoduo Li et al.

Summary: Alginate, with advantages such as ionic crosslinking and biocompatibility, is widely used in nutraceutical delivery systems. Various types of alginate-based delivery systems are currently available, with ongoing research for further improvements and developments in the field.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2021)

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Article Instruments & Instrumentation

An overview of chitosan and its application in infectious diseases

Qingye Meng et al.

Summary: Infectious diseases like COVID-19, SARS, Ebola, and AIDS pose a global health threat, leading researchers to develop new antiviral and antibacterial drugs. Natural material chitosan, when used in collaboration with traditional medicine, has shown to enhance anti-infection capabilities.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Article Pharmacology & Pharmacy

Alginate nanoparticles as ocular drug delivery carriers

Sogol Kianersi et al.

Summary: The eye is the most susceptible organ of the body, requiring a special drug delivery system to improve drug bioavailability and reduce dosing frequency. By preparing alginate nanoparticles and conducting coating modification, sustained drug release, increased drug adhesion to ocular tissue, and decreased need for duplicate treatment can be achieved.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Improvement of the Antimicrobial Activity of Oregano Oil by Encapsulation in Chitosan-Alginate Nanoparticles

Krassimira Yoncheva et al.

Summary: The encapsulation of oregano oil in chitosan-alginate nanoparticles significantly enhances its antimicrobial activity and thermal stability. OrO-NP exhibit lower minimal inhibitory concentrations and cytotoxicity compared to pure oregano oil, making them a promising delivery system for development of food additives.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Connecting the dots in drug delivery: A tour d'horizon of chitosan-based nanocarriers system

Sheersha Pramanik et al.

Summary: Chitosan, as a drug carrier, has a wide range of applications due to its biodegradability, biocompatibility, and other excellent properties, such as influencing drug release rate and antimicrobial properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications

Yang Gao et al.

Summary: The review highlights the recent progress in fabricating chitosan-based biomaterials using microfluidic technology, emphasizing the precise control over morphology and microstructures, as well as the potential applications of chitosan-based materials in the field of biomedicine.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Pharmacology & Pharmacy

Doxorubicin-loaded chitosan-alginate nanoparticles with dual mucoadhesive functionalities for intravesical chemotherapy

Nitjawan Sahatsapan et al.

Summary: This study synthesized dual-functional mucoadhesive nanoparticles for intravesical chemotherapy, demonstrating effective drug delivery and potent inhibitory effects against cancer cells, showing potential clinical applications.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Review Polymer Science

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Vera Alexandra Spirescu et al.

Summary: Infectious diseases remain a major health threat due to limitations of antimicrobial drugs and microbial resistance. Research has shifted towards finding novel antimicrobial agents, with nanotechnology and polymeric nanoparticles showing potential advantages.

POLYMERS (2021)

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Article Instruments & Instrumentation

A chitosan-based nanosystem as pneumococcal vaccine delivery platform

Sandra Robla et al.

Summary: Chitosan-based nanosystems conjugated with Streptococcus pneumoniae cell membrane protein PsaA have shown promising results in enhancing antigen uptake by immune cells and activating specific T cells, thus generating an adaptive immune response against pneumococcus. The designed nanocapsules, with good stability and positive charge, displayed increased association rates with PsaA compared to non-covalent conjugation, and exhibited no cytotoxic effects at certain concentrations in cell culture media. Furthermore, the nanocapsules were shown to activate CD4 and CD8 T lymphocytes, as well as promote the maturation of immature dendritic cells, suggesting their potential as a nasal vaccine delivery method.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Chemistry, Physical

Polymer-Based Nanosystems-A Versatile Delivery Approach

Adelina-Gabriela Niculescu et al.

Summary: Polymer-based nanoparticles customized for size, morphology, and surface properties are gaining attention for drug, biomolecule, and gene delivery. They protect payloads from degradation and sustain controlled drug release, reducing clearance and increasing stability, solubility, and optimal concentration at target sites, especially in vaccine development.

MATERIALS (2021)

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Article Polymer Science

Antimicrobial Activity of Ca-Alginate/Chitosan Nanocomposite Loaded with Camptothecin

Wafa Al-Gethami et al.

Summary: This study aimed to prepare antimicrobial nanocomposites consisting of alginate, chitosan, and camptothecin. The results showed a strong chemical interaction between alginate and chitosan, and successful loading of camptothecin in both Ca-Alg(2)/CPT and Ca-Alg(2)-CH/CPT nanomaterials. Antimicrobial tests revealed that Ca-Alg(2)-CH/CPT nanocomposite was more effective against Escherichia coli and Klebsiella pneumoniae, while Ca-Alg(2)/CPT was less efficient in killing all three types of bacteria. PCR analysis indicated changes in bacterial genetic material due to the nanomaterial processing.

POLYMERS (2021)

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Review Chemistry, Applied

Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy

Milad Ashrafizadeh et al.

Summary: Gene therapy using siRNA faces challenges, but chitosan nanoparticles as carriers show promise in overcoming siRNA issues and demonstrating potential in cancer therapy.

CARBOHYDRATE POLYMERS (2021)

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Review Chemistry, Multidisciplinary

An Up-to-Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications

Andrea Dodero et al.

Summary: Alginate, a naturally occurring polysaccharide derived from brown algae, has shown great potential in biomedical and pharmaceutical applications, particularly in drug delivery and tissue engineering. Recent advancements in alginate-based nanostructures have demonstrated enhanced capabilities in targeted drug delivery and tissue regeneration. This review provides an overview of the latest developments in the preparation of alginate-based nanoparticles and nanofibers for various medical purposes.

ADVANCED MATERIALS INTERFACES (2021)

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Review Chemistry, Multidisciplinary

Chitosan as an Underrated Polymer in Modern Tissue Engineering

Marta Kolodziejska et al.

Summary: Chitosan, with its unique chemical, biological, and physical properties, is extensively used in tissue engineering as a main component in biomaterials. It can be modified and blended to meet specific requirements, making it versatile for various applications such as membranes, scaffolds, drug carriers, and hydrogels.

NANOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Posterior Segment Ophthalmic Drug Delivery: Role of Muco-Adhesion with a Special Focus on Chitosan

Ayah Mohammad Burhan et al.

Summary: This study presents an overview of posterior segment eye diseases, barriers to topical drug delivery, and the application of chitosan in ophthalmic drug delivery. It discusses how mucoadhesive formulations can help enhance drug delivery to the posterior eye segment.

PHARMACEUTICS (2021)

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Article Biochemistry & Molecular Biology

Investigation the Effects of Green-Synthesized Copper Nanoparticles on the Performance of Activated Carbon-Chitosan-Alginate for the Removal of Cr(VI) from Aqueous Solution

Inas A. Ahmed et al.

Summary: In this study, green nano-zerovalent copper, activated carbon, chitosan, and alginate nanocomposites were produced and utilized for the removal of chromium (VI) from contaminated solutions. Among the prepared nanocomposites, GnZVCu/AC-CS-alginate showed the highest adsorption efficiency for Cr+6, highlighting its potential for chromium segregation.

MOLECULES (2021)

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Review Polymer Science

Antimicrobial Actions and Applications of Chitosan

Cai-Ling Ke et al.

Summary: Chitosan, a naturally occurring product, has biocompatibility, biodegradability, and non-toxic properties, making it applicable in many areas. Its broad-spectrum antimicrobial activity provides great commercial potential, but varies depending on its physicochemical characteristics and type of microorganism. Understanding the fundamental properties and modes of antimicrobial action of chitosan, as well as how microorganisms genetically respond to it, can lead to better applications.

POLYMERS (2021)

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Review Immunology

Chitosan-Based Nanoparticles Against Viral Infections

Homa Boroumand et al.

Summary: Viral infections can damage host cells and compromise the host immune system. Nanotechnology offers potential solutions for developing effective antiviral drugs with enhanced selectivity to protect healthy cells.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Infectious Diseases

Bacterial Resistance to Antimicrobial Agents

Manuel F. Varela et al.

Summary: This review briefly summarizes various antimicrobial resistance mechanisms harbored within infectious bacteria, including active antimicrobial efflux, reduced drug entry into cells, enzymatic metabolism to inactive products, etc.

ANTIBIOTICS-BASEL (2021)

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Review Oncology

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Javad Sharifi-Rad et al.

Summary: The study highlights the importance of chitosan-based nanomaterials in medicine and their potential applications in nanomedicine. It discusses the latest research on utilizing chitosan nanoparticles for creating improved drug release systems, enhanced bioavailability, and reduced pharmacological toxicity. Additionally, the manuscript reviews the progress on the stability, use, and safety of drug nanoencapsulation with chitosan.

CANCER CELL INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Synthesis of rifaximin loaded chitosan-alginate core-shell nanoparticles (Rif@CS/Alg-NPs) for antibacterial applications

Deepak Kumar et al.

Summary: The study successfully synthesized rifaximin-loaded chitosan-alginate core-shell nanoparticles (Rif@CS/Alg-NPs) with excellent antibacterial activities against various bacteria. The nanoparticles showed no cytotoxicity towards human lung adenocarcinoma cell line A549 and exhibited drug release at different pH levels.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

Chitosan-alginate core-shell-corona shaped nanoparticles of dimethyl fumarate in orodispersible film to improve bioavailability in treatment of multiple sclerosis: Preparation, characterization and biodistribution in rats

Suhani Sinha et al.

Summary: DMF-loaded chitosan-alginate nanoparticles in oral films showed enhanced bioavailability in multiple sclerosis treatment, leading to potential dose reduction and reduced side effects compared to conventional oral film formulations. In-vitro and in-vivo studies confirmed sustained release and improved pharmacokinetic parameters of DMF nanoparticles in the orally disintegrating films.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Revolutionizing polymer-based nanoparticle-linked vaccines for targeting respiratory viruses: A perspective

Yinghan Chan et al.

Summary: Viral respiratory tract infections have a significant impact on global health and socio-economic growth, with vaccination being the primary method of prevention. However, traditional vaccines have limitations, prompting the need for novel vaccine delivery vehicles to enhance immune responses. This review explores how polymer-based nanoparticles can be integrated with vaccine development to effectively combat viral respiratory tract infections.

LIFE SCIENCES (2021)

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Article Polymer Science

Application of Chitosan/Alginate Nanocomposite Incorporated with Phycosynthesized Iron Nanoparticles for Efficient Remediation of Chromium

Fahad M. Almutairi et al.

Summary: The study innovatively synthesized nanopolymer composites using biopolymers and nanomaterials to remove hexavalent chromium (Cr6+) from water. By combining chitosan and alginate with phycosynthesized iron nanoparticles, effective removal of Cr6+ was achieved through adsorption.

POLYMERS (2021)

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Article Microbiology

Antimicrobial Activities of Alginate and Chitosan Oligosaccharides Against Staphylococcus aureus and Group B Streptococcus

Mostafa Asadpoor et al.

Summary: AOS and COS affect the growth of GBS V and S. aureus wood 46, functioning as anti-biofilm agents. The combination of AOS and COS with different antibiotics may provide new opportunities to combat antimicrobial resistance.

FRONTIERS IN MICROBIOLOGY (2021)

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Review Chemistry, Analytical

A Brief Review on Additive Manufacturing of Polymeric Composites and Nanocomposites

Vahid Monfared et al.

Summary: This research article provides a mini-review study on additive manufacturing of polymeric matrix composites and nanocomposites, exploring methods, important results, challenges, and potential future research directions in this field.

MICROMACHINES (2021)

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Review Pharmacology & Pharmacy

Nano and Microparticles as Potential Oral Vaccine Carriers and Adjuvants Against Infectious Diseases

Seyed Davoud Jazayeri et al.

Summary: Mucosal surfaces are the initial site of infection for most diseases, making oral vaccination crucial for providing protection as the first line of defense through stimulation of immune responses at both systemic and mucosal levels. Successful oral vaccines must overcome the challenges posed by the harsh gastrointestinal environment and low immunogenicity, which can be addressed through the development of delivery systems and adjuvants like nanoparticles and microparticles.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Chemistry, Applied

Exploration of Antioxidant, Antibacterial Activities of Green Synthesized Hesperidin Loaded PLGA Nanoparticles

Krithiga Balakrishnan et al.

Summary: This study demonstrates the antioxidant and antimicrobial potential of hesperidin loaded PLGA nanoparticles, showing better activity compared to free hesperidin. The nanoparticles also exhibited the ability to inhibit biofilm formation, suggesting their promising application as a bio compound for medical treatments.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

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Review Polymer Science

Gel-Based Materials for Ophthalmic Drug Delivery

Roberta Cassano et al.

Summary: This review describes the main applications of gel-based materials in ophthalmology, which have been studied for their potential to increase precorneal residence time and reduce drug loss. These materials are used in eye drops, in situ gelling formulations, intravitreal injections, and therapeutic contact lenses.

GELS (2021)

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Review Pharmacology & Pharmacy

Alginate and alginate composites for biomedical applications

Raha Ahmad Raus et al.

Summary: Alginate is an edible heteropolysaccharide widely used in food, textile, and paper industries, as well as in biomedical applications for wound healing and tissue regeneration. To overcome the limitations of alginate, various materials have been added to create sturdy composite materials with improved mechanical properties, healing capability, and tissue regeneration promotion.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Multidisciplinary

Smart nanocomposites of chitosan/alginate nanoparticles loaded with copper oxide as alternative nanofertilizers

Marco Leonardi et al.

Summary: An innovative hybrid nanocomposite fertilizer was designed in this study, utilizing environmentally-friendly chemical preparation to achieve stability and size control. The nanocomposite effectively released CuO nanoparticles and demonstrated significant benefits in seedling growth and development.

ENVIRONMENTAL SCIENCE-NANO (2021)

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Article Chemistry, Applied

Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone

Xiaoyue Xu et al.

CARBOHYDRATE POLYMERS (2020)

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Review Chemistry, Applied

Fabrication challenges and trends in biomedical applications of alginate electrospun nanofibers

Mandokht Akbari Taemeh et al.

CARBOHYDRATE POLYMERS (2020)

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Review Chemistry, Multidisciplinary

Drug delivery applications of chitin and chitosan: a review

Rabinarayan Parhi

ENVIRONMENTAL CHEMISTRY LETTERS (2020)

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Review Ophthalmology

Advances in ocular drug delivery systems

Jennifer J. Kang-Mieler et al.

EYE (2020)

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Review Polymer Science

Ionotropic gelation method in the synthesis of nanoparticles/microparticles for biomedical purposes

Seidy Pedroso-Santana et al.

POLYMER INTERNATIONAL (2020)

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Article Multidisciplinary Sciences

Characterization of chitosan/alginate/lovastatin nanoparticles and investigation of their toxic effects in vitro and in vivo

Hoang Thai et al.

SCIENTIFIC REPORTS (2020)

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Review Chemistry, Applied

Review on marine carbohydrate-based gold nanoparticles represented by alginate and chitosan for biomedical application

Xiangyan Chen et al.

CARBOHYDRATE POLYMERS (2020)

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Article Biochemistry & Molecular Biology

Chitosan-oleic acid-sodium alginate a hybrid nanocarrier as an efficient delivery system for enhancement of lutein stability and bioavailability

Veeresh Toragall et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Chemistry, Multidisciplinary

Development of Polyelectrolyte Complexes for the Delivery of Peptide-Based Subunit Vaccines against Group A Streptococcus

Lili Zhao et al.

NANOMATERIALS (2020)

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Article Instruments & Instrumentation

Rifampicin loaded in alginate/chitosan nanoparticles as a promising pulmonary carrier against Staphylococcus aureus

I. R. Scolari et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Biotechnology & Applied Microbiology

Hydrogel Biomaterials for Application in Ocular Drug Delivery

Courtney R. Lynch et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Pharmacology & Pharmacy

Exploring Endolysin-Loaded Alginate-Chitosan Nanoparticles as Future Remedy for Staphylococcal Infections

Jasjeet Kaur et al.

AAPS PHARMSCITECH (2020)

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Review Biochemistry & Molecular Biology

Advances and applications of chitosan-based nanomaterials as oral delivery carriers: A review

Xuqian Lang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Instruments & Instrumentation

Chitosan-based particulate systems for drug and vaccine delivery in the treatment and prevention of neglected tropical diseases

Sevda Senel et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Article Chemistry, Medicinal

Electrosprayed Alginate Nanoparticles as CRISPR Plasmid DNA Delivery Carrier: Preparation, Optimization, and Characterization

Batoul Alallam et al.

PHARMACEUTICALS (2020)

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Review Pharmacology & Pharmacy

Topical Ocular Delivery of Nanocarriers: A Feasible Choice for Glaucoma Management

Karthikeyan Kesavan et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Review Polymer Science

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Alexandra Zamboulis et al.

POLYMERS (2020)

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Article Pharmacology & Pharmacy

Encapsulation of doxorubicin in chitosan-alginate nanoparticles improves its stability and cytotoxicity in resistant lymphoma L5178 MDR cells

Krassimira Yoncheva et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Review Chemistry, Multidisciplinary

A Review of Biodegradable Natural Polymer-Based Nanoparticles for Drug Delivery Applications

Humaira Idrees et al.

NANOMATERIALS (2020)

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Review Chemistry, Medicinal

Recent Progress of Chitosan and Chitosan Derivatives-Based Nanoparticles: Pharmaceutical Perspectives of Oral Insulin Delivery

Salma Seyam et al.

PHARMACEUTICALS (2020)

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Article Biochemistry & Molecular Biology

Chitosan-coated alginate micro-particles delivery of active principles through conventional pelleted food - A study in Tilapia (Oreochromis niloticus)

E. Giacomello et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Chemistry, Multidisciplinary

Understanding Nanoparticle Toxicity to Direct a Safe-by-Design Approach in Cancer Nanomedicine

Jossana A. Damasco et al.

NANOMATERIALS (2020)

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Review Polymer Science

Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review

Francivandi Coelho Barbosa et al.

POLYMERS (2020)

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Review Chemistry, Applied

Chitosan: A promising therapeutic agent and effective drug delivery system in managing diabetes mellitus

Sanjib Sarkar et al.

CARBOHYDRATE POLYMERS (2020)

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Article Materials Science, Biomaterials

Mucoadhesive Micro-/Nano Carriers in Ophthalmic Drug Delivery: an Overview

Jitendra B. Naik et al.

BIONANOSCIENCE (2020)

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Article Pharmacology & Pharmacy

Chitosan-sodium Alginate Nanoparticle as a Promising Approach for Oral Delivery of Rosuvastatin Calcium: Formulation, Optimization and In vitro Characterization

Md Ali Mujtaba et al.

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL (2020)

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Article Pharmacology & Pharmacy

Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

Jafar Mosafer et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Review Pharmacology & Pharmacy

Chitosan-based nanoparticles as drug delivery systems: a review on two decades of research

Sweet Naskar et al.

JOURNAL OF DRUG TARGETING (2019)

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Article Biochemistry & Molecular Biology

Chitosan/alginate nanoparticles as a promising carrier of novel curcumin diethyl diglutarate

Feuangthit Niyamissara Sorasitthiyanukarn et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Pharmacology & Pharmacy

Optimization and in-vitro/in-vivo evaluation of doxorubicin-loaded chitosan-alginate nanoparticles using a melanoma mouse model

Krassimira Yoncheva et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Chemistry, Physical

Microfluidic formation of core-shell alginate microparticles for protein encapsulation and controlled release

Lei Yu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Review Pharmacology & Pharmacy

Chitosan-based nanoparticles: An overview of biomedical applications and its preparation

Sweet Naskar et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Review Pharmacology & Pharmacy

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Bahman Homayun et al.

PHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

Synergistic Effects of Photo-Irradiation and Curcumin-Chitosan/Alginate Nanoparticles on Tumor Necrosis Factor-Alpha-Induced Psoriasis-Like Proliferation of Keratinocytes

Clinton Gomez et al.

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Article Biochemistry & Molecular Biology

Chitosan nanopolymers: An overview of drug delivery against cancer

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Applications of Nanotechnology in Plant Growth and Crop Protection: A Review

Yifen Shang et al.

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Article Pharmacology & Pharmacy

Chitosan-Coated Alginate Nanoparticles Enhanced Absorption Profile of Insulin via Oral Administration

Mohd H. M. Jaafar et al.

CURRENT DRUG DELIVERY (2019)

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Article Pharmacology & Pharmacy

Development and characterization of alginate/chitosan nanoparticulate system for hydrophobic drug encapsulation

T. Nalini et al.

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Article Materials Science, Biomaterials

Magnetic and self-healing chitosan-alginate hydrogel encapsulated gelatin microspheres via covalent cross-linking for drug delivery

Xueyun Chen et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Engineering, Biomedical

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Kailei Xu et al.

BIOMATERIALS (2019)

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Article Chemistry, Physical

Alginate-chitosan coated layered double hydroxide nanocomposites for enhanced oral vaccine delivery

Xinying Yu et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Multidisciplinary Sciences

Immobilization of planktonic algal spores by inkjet printing

Hwa-Rim Lee et al.

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Article Chemistry, Applied

Yeast cells in double layer calcium alginate-chitosan microcapsules for sparkling wine production

Ilaria Benucci et al.

FOOD CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines

Zheng Jin et al.

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Microbial activity and swelling behavior of chitosan/polyvinyl alcohol/sodium alginate semi-natural terpolymer interface containing amoxicillin for wound dressing applications

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BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2019)

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Self-assembly pH-sensitive chitosan/alginate coated polyelectrolyte complexes for oral delivery of insulin

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Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery

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Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery

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Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment

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Article Engineering, Environmental

New magnetic chitosan/alginate/Fe3O4@SiO2 hydrogel composites applied for removal of Pb(II) ions from aqueous systems

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Drug transport mechanisms and in vitro release kinetics of vancomycin encapsulated chitosan-alginate polyelectrolyte microparticles as a controlled drug delivery system

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Development of probiotic-loaded microcapsules for local delivery: Physical properties, cell release and growth

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pH-responsive chitosan/alginate polyelectrolyte complex membranes reinforced by tripolyphosphate

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EUROPEAN POLYMER JOURNAL (2018)

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Chitosan-sodium alginate nanoparticle as a delivery system for ε-polylysine: Preparation, characterization and antimicrobial activity

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Chitosan-alginate nano-carrier for transdermal delivery of pirfenidone in idiopathic pulmonary fibrosis

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Nanocoatings for Chronic Wound Repair-Modulation of Microbial Colonization and Biofilm Formation

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Optimization and characterization of nisin-loaded alginate-chitosan nanoparticles with antimicrobial activity in lean beef

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Chitosan/alginate microparticles for the oral delivery of fowl typhoid vaccine: Innate and acquired immunity

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Nasal delivery of chitosan/alginate nanoparticle encapsulated bee (Apis mellifera) venom promotes antibody production and viral clearance during porcine reproductive and respiratory syndrome virus infection by modulating T cell related responses

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Biodegradable Alginate-Chitosan Hollow Nanospheres for Codelivery of Doxorubicin and Paclitaxel for the Effect of Human Lung Cancer A549 Cells

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Recent advances of polysaccharide-based nanoparticles for oral insulin delivery

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Review Biochemistry & Molecular Biology

Potential applications of engineered nanoparticles in medicine and biology: an update

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Chitosan/alginate nanoparticles as a promising approach for oral delivery of curcumin diglutaric acid for cancer treatment

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Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Wenxing Song et al.

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Review Critical Care Medicine

Antimicrobial Resistance in the Intensive Care Unit: A Focus on Gram-Negative Bacterial Infections

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Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

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Evaluation of biocompatibility and antioxidant efficiency of chitosan-alginate nanoparticles loaded with quercetin

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Carrageenan-stabilized chitosan alginate nanoparticles loaded with ethionamide for the treatment of tuberculosis

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Chitosan-based composite hydrogels for biomedical applications

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MACROMOLECULAR RESEARCH (2017)

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Release Behavior and Antibacterial Activity of Chitosan/Alginate Blends with Aloe vera and Silver Nanoparticles

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Article Clinical Neurology

Curcumin-loaded chitosan-alginate-STPP nanoparticles ameliorate memory deficits and reduce glial activation in pentylenetetrazol-induced kindling model of epilepsy

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Hepatoprotective and antioxidant activity of quercetin loaded chitosan/alginate particles in vitro and in vivo in a model of paracetamol-induced toxicity

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Alginate coated chitosan core-shell nanoparticles for efficient oral delivery of naringenin in diabetic animals-An in vitro and in vivo approach

Subhajit Maity et al.

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Review Tropical Medicine

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Nanoparticles Based on Chitosan as Carriers for the Combined Herbicides Imazapic and Imazapyr

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SCIENTIFIC REPORTS (2016)

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Article Chemistry, Applied

Development and characterization of alginate coated low molecular weight chitosan nanoparticles as new carriers for oral vaccine delivery in mice

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Potential chitosan-coated alginate nanoparticles for ocular delivery of daptomycin

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Development and evaluation of alginate-chitosan nanocapsules for controlled release of acetamiprid

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Article Food Science & Technology

Preparation of Chitosan-Alginate Nanoparticles for Trans-cinnamaldehyde Entrapment

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Chitosan: Gels and Interfacial Properties

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Design and characterization of chitosan-alginate microspheres for ocular delivery of azelastine

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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2014)

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Chitosan coated sodium alginate-chitosan nanoparticles loaded with 5-FU for ocular delivery: In vitro characterization and in vivo study in rabbit eye

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Paraquat-loaded alginate/chitosan nanoparticles: Preparation, characterization and soil sorption studies

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Effect of the preparation method on the drug loading of alginate-chitosan microspheres

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EXPRESS POLYMER LETTERS (2010)

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