期刊
NANOMATERIALS
卷 12, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/nano12020205
关键词
magnetic nanoparticles; magnetic hyperthermia; magnetic relaxation; magnetic resonance imaging; biosensor; lateral flow immunoassays; inductive sensing
类别
资金
- Spanish Ministry of Economy and Competitiveness [MAT2017-84959-C2-1-R, MCI-20-EIN2020-112354]
- Principality of Asturias (Spain) [FICYT/IDI/2021/000100, FICYT/IDI/2021/000273]
- RA-TB/CFATR/LMF multiannual research program [04-4-1142-2021/2025item 34JINR, 365/11.05.2021]
- Italian National research Council project Ferro-Tera
- Severo Ochoa fellowship (Consejeria de Educacion y Cultura del Gobierno del Principado de Asturias) [BP19-141]
- University of Oviedo, the Ministry of Education, Culture and Sport, and Banco Santander [CEI15-24]
- University Technological Institute of Asturias (IUTA) [SV-21-GIJON-03]
- Romanian Academy
Public health is a significant challenge in today's society, and early diagnosis and treatment of cancer are a priority. Magnetic nanoparticles have great potential in various biomedical applications. This study focuses on the polymeric coating of superparamagnetic iron oxide nanoparticles and analyzes their performance in resonance imaging, magnetic hyperthermia, and biosensing. Different types of fatty acid coatings were examined, and their characteristics were evaluated.
Today, public health is one of the most important challenges in society. Cancer is the leading cause of death, so early diagnosis and localized treatments that minimize side effects are a priority. Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents, detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition, they provide the particles with functional chemical groups that allow their bioconjugation. This work analyzes three types of self-assembled bilayer fatty acid coatings of superparamagnetic iron oxide nanoparticles: oleic, lauric, and myristic acids. We characterize the particles magnetically and structurally and study their potential for resonance imaging, magnetic hyperthermia, and labeling for biosensing in lateral flow immunoassays. We found that the myristic acid sample reported a large r2 relaxivity, superior to existing iron-based commercial agents. For magnetic hyperthermia, a significant specific absorption rate value was obtained for the oleic sample. Finally, the lauric acid sample showed promising results for nanolabeling.
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