Microwave-Assisted Sol-Gel Preparation of the Nanostructured Magnetic System for Solid-Phase Synthesis

This work describes a new synthesis method for core-shell magnetite nanoparticles with a secondary silica shell, functionalized with a linker system (Fe3O4-PABA-SiO2-linker) using a microwave-assisted heating technique. The functionalized solid nanomaterial was used for the nanophase synthesis of peptides (Fmoc route) as a solid support. The co-precipitation method was selected to obtain magnetite nanoparticles and sol-gel technique for silica coating using a microwave-assisted (MW) procedure. The magnetic properties of the nanoparticle core offer the advantage of a quick and easy alternative for the magnetic separation of the product from the reaction mixture, facilitating all the intermediary washing and separation operations. The intermediate and final materials were analyzed by advanced characterization methods. The effectiveness of the nanophase peptide synthesis using this nanostructured material as solid support was demonstrated for a short peptide sequence.

Automated summary

This study introduces a new synthesis method for core-shell magnetite nanoparticles with a secondary silica shell, functionalized with a linker system using microwave-assisted heating technique. The functionalized solid nanomaterial is utilized as a solid support for nanophase peptide synthesis, demonstrating effective synthesis of a short peptide sequence. Experimental results show that the magnetic properties of the nanoparticle core facilitate quick and easy magnetic separation of the product, streamlining intermediary washing and separation operations.