期刊
NANOMATERIALS
卷 12, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano12040682
关键词
plasma polymerization; silica nanoparticles; protein corona; inflammatory responses
类别
资金
- ARC [DP180101254]
- NHMRC [GNT1194466]
- Alexander von Humboldt Foundation for Fellowship for Experienced Researchers
This study reveals the influence of nanoparticle surface functionalization on protein corona formation and innate immune cellular responses. The results show significant differences in protein corona composition and subsequent inflammatory consequences based on surface chemistry. The findings demonstrate the potential to direct physiological responses to nanomaterials via tailoring their surface chemical composition.
Nanoparticles are widely used for biomedical applications such as vaccine, drug delivery, diagnostics, and therapeutics. This study aims to reveal the influence of nanoparticle surface functionalization on protein corona formation from blood serum and plasma and the subsequent effects on the innate immune cellular responses. To achieve this goal, the surface chemistry of silica nanoparticles of 20 nm diameter was tailored via plasma polymerization with amine, carboxylic acid, oxazolines, and alkane functionalities. The results of this study show significant surface chemistryinduced differences in protein corona composition, which reflect in the subsequent inflammatory consequences. Nanoparticles rich with carboxylic acid surface functionalities increased the production of pro-inflammatory cytokines in response to higher level of complement proteins and decreased the number of lipoproteins found in their protein coronas. On another hand, amine rich coatings led to increased expressions of anti-inflammatory markers such as arginase. The findings demonstrate the potential to direct physiological responses to nanomaterials via tailoring their surface chemical composition.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据