期刊
NANOMATERIALS
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/nano11102513
关键词
nanocrystals; erythrocyte membrane; drug delivery; antitumor effect
类别
资金
- Science and Technology Planning Project of Jiangsu Province of China [BE2019738]
- Joint scientific research project of Sino-foreign cooperation platform in NJTECH university
- Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture
The simple and functional modification of nanoparticle surfaces is used for efficient delivery of chemotherapeutic drugs for cancer treatment. Constructing a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes shows superior properties compared to traditional free drug treatments, providing a promising foundation for further development and clinical trials of anti-cancer drug nanocarriers in the future.
The simple and functional modification of the nanoparticle's surface is used to efficiently deliver chemotherapeutic drugs for anti-cancer treatment. Here, we construct a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes for the treatment of mouse breast cancer models. Compared with traditional free drug treatments, the biodegradable natural red blood cell membrane is combined with pure crystalline drugs. The nanoparticles obtained by the preparation method have superior properties, such as good stability, significantly delaying the release of drugs and enhancing the inhibitory effect on tumor cells. This study shows that the design of RBC as an outsourced drug delivery system provides a promising foundation for the continued development, clinical trials, and nanomedicine research of anti-cancer drug nanocarriers in the future.
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