期刊
LANCET RESPIRATORY MEDICINE
卷 10, 期 1, 页码 95-106出版社
ELSEVIER SCI LTD
DOI: 10.1016/S2213-2600(21)00408-2
关键词
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资金
- UK Research and Innovation
- National Institute for Health Research through the UK Coronavirus Immunology Consortium (UK-CIC)
- General Sir John Monash Scholarship - General Sir John Monash Foundation
- Newcastle University
Post-mortem lung tissue analysis reveals a high degree of heterogeneity in COVID-19 lung disease, with different phenotypes and pathophysiological processes. This understanding is crucial for patient management and the development of treatment strategies.
The lungs are the main site that is affected in severe COVID-19, and post-mortem lung tissue provides crucial insights into the pathophysiology of severe disease. From basic histology to state-of-the-art multiparameter digital pathology technologies, post-mortem lung tissue provides snapshots of tissue architecture, and resident and inflammatory cell phenotypes and composition at the time of death. Contrary to early assumptions that COVID-19 in the lungs is a uniform disease, post-mortem findings have established a high degree of disease heterogeneity. Classic diffuse alveolar damage represents just one phenotype, with disease divisible by early and late progression as well as by pathophysiological process. A distinct lung tissue state occurs with secondary infection; extrapulmonary causes of death might also originate from a pathological process in the lungs linked to microthrombosis. This heterogeneity of COVID-19 lung disease must be recognised in the management of patients and in the development of novel treatment strategies.
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