期刊
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
卷 45, 期 4, 页码 787-796出版社
SPRINGER
DOI: 10.1007/s40618-021-01709-y
关键词
Testosterone; 2; 4-D; Herbicides; Hypogonadism; Endocrine disruption
This study investigated the relationship between urinary concentrations of 2,4-D and serum testosterone levels among U.S. adult males, finding a significant negative association. However, no significant associations were found between 2,4-D and the odds of low testosterone based on a cutoff defining abnormally low testosterone levels. Further research is needed to confirm these findings and explore potential biological mechanisms.
Background Previous studies have investigated associations between herbicides such as 2,4-Dichlorophenoxyacetic acid (2,4-D) and dyshormonogenesis, specifically low testosterone, in human, rodent, and cell models, but results have been conflicting and inconclusive. Methods Using data from a cross-sectional study of 456 adult men in the 2013-2014 NHANES survey cycle, we examined the relationship between urinary concentrations of 2,4-D and serum testosterone levels. Results Multivariable regression models adjusting for potential confounders revealed a significant, negative association between urinary 2,4-D and mean serum testosterone among U.S. adult males (beta = - 11.4 ng/dL, p = 0.02). Multivariable logistic regression models using a cutoff defining abnormally low testosterone (i.e., serum testosterone < 300 ng/dL) revealed no significant associations between 2,4-D and the odds of low testosterone. Conclusion These findings expand on previous literature implicating a role for 2,4-D in the etiology of low testosterone and dyshormonogenesis. Future studies are warranted to corroborate these findings, determine clinical significance, and to investigate the proposed potential biological mechanisms underlying this association.
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