期刊
GENES
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/genes13020244
关键词
microRNA; EMT; angiogenesis; drug resistance
资金
- South African Medical Research Council (SAMRC) [23108]
- National Research Foundation (NRF) [138139]
MicroRNAs (miRNA) are small non-coding RNAs that regulate oncogenes or tumor suppressor genes by suppressing gene translation or promoting mRNA translation into proteins. Circulating miRNAs can serve as prognostic markers for cancer, aiding in early detection. miRNA-related EMT can be targeted for therapeutic purposes in glioblastomas.
MicroRNAs (miRNA) are small non-coding RNAs that are 20-23 nucleotides in length, functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators that regulate gene expression by suppressing gene translation through gene silencing/degradation, or by promoting translation of messenger RNA (mRNA) into proteins. Circulating miRNAs have attracted attention as possible prognostic markers of cancer, which could aid in the early detection of the disease. Epithelial to mesenchymal transition (EMT) has been implicated in tumorigenic processes, primarily by promoting tumor invasiveness and metastatic activity; this is a process that could be manipulated to halt or prevent brain metastasis. Studies show that miRNAs influence the function of EMT in glioblastomas. Thus, miRNA-related EMT can be exploited as a potential therapeutic target in glioblastomas. This review points out the interrelation between miRNA and EMT signatures, and how they can be used as reliable molecular signatures for diagnostic purposes or targeted therapy in glioblastomas.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据