期刊
GENES
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/genes12101507
关键词
plasma membrane calcium ATPase; PMCA; autism; schizophrenia; Alzheimer's disease; calcium homeostasis; synaptopathy; 15q24 microdeletion syndrome
资金
- German Federal Ministry of Education and Research (BMBF grant CONICYT)
- China Scholarship Council [201506290028, 202008080376]
- Center for Behavioral and Brain Sciences (LSA-fellowship)
- DAAD [57514679]
- Leibniz Institute for Neurobiology (LIN)
Neuroplastin, a cell recognition glycoprotein, plays a role in cognitive function and is associated with neuropsychiatric and neurodegenerative diseases. Understanding the molecular features of neuroplastin and its binding partners may have implications for improving treatments for these diseases.
Molecular mechanisms underlying neuropsychiatric and neurodegenerative diseases are insufficiently elucidated. A detailed understanding of these mechanisms may help to further improve medical intervention. Recently, intellectual abilities, creativity, and amnesia have been associated with neuroplastin, a cell recognition glycoprotein of the immunoglobulin superfamily that participates in synapse formation and function and calcium signaling. Data from animal models suggest a role for neuroplastin in pathways affected in neuropsychiatric and neurodegenerative diseases. Neuroplastin loss or disruption of molecular pathways related to neuronal processes has been linked to various neurological diseases, including dementia, schizophrenia, and Alzheimer's disease. Here, we review the molecular features of the cell recognition molecule neuroplastin, and its binding partners, which are related to neurological processes and involved in learning and memory. The emerging functions of neuroplastin may have implications for the treatment of diseases, particularly those of the nervous system.
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