期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.755124
关键词
liver; abdominal obesity; free fatty acid; triglycerides; glucose tolerance
类别
资金
- Australian National Health and Medical Research Council [AP1158186]
- University of Technology Sydney
Tobacco smoking increases metabolic disorder risk, while e-cigarette vapour, especially nicotine-containing vapour, can improve glucose tolerance and reduce fat mass in mice fed with a high-fat diet. However, e-vapour without nicotine increases lipid content in blood and liver. Changes in liver metabolic markers may be adaptive responses rather than causal, and future studies can explore how e-vapour affects metabolic profiles under different dietary conditions.
Tobacco smoking increases the risk of metabolic disorders due to the combination of harmful chemicals, whereas pure nicotine can improve glucose tolerance. E-cigarette vapour contains nicotine and some of the harmful chemicals found in cigarette smoke at lower levels. To investigate how e-vapour affects metabolic profiles, male Balb/c mice were exposed to a high-fat diet (HFD, 43% fat, 20kJ/g) for 16weeks, and e-vapour in the last 6weeks. HFD alone doubled fat mass and caused dyslipidaemia and glucose intolerance. E-vapour reduced fat mass in HFD-fed mice; only nicotine-containing e-vapour improved glucose tolerance. In chow-fed mice, e-vapour increased lipid content in both blood and liver. Changes in liver metabolic markers may be adaptive responses rather than causal. Future studies can investigate how e-vapour differentially affects metabolic profiles with different diets.
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