4.6 Review

Issues on Trainability

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Article Physiology

Responders and non-responders to aerobic exercise training: beyond the evaluation of (V) over dotO2max

Felipe Mattioni Maturana et al.

Summary: The study aimed to investigate cardiovascular and metabolic adaptations to exercise training among participants with different levels of responsiveness to (V)dot O(2max), finding that responders showed greater improvements in peak power output, second lactate threshold, and microvascular responsiveness, while non-responders had a greater increase in cycling efficiency. No significant differences were observed in other health-related parameters.

PHYSIOLOGICAL REPORTS (2021)

Article Physiology

The Comparative Methylome and Transcriptome After Change of Direction Compared to Straight Line Running Exercise in Human Skeletal Muscle

Mohd-Firdaus Maasar et al.

Summary: The study found that different types of exercises, especially change of direction exercise, may induce higher exercise intensity and greater genome-wide hypomethylation features post-exercise, which are associated with changes in gene expression levels related to exercise adaptation.

FRONTIERS IN PHYSIOLOGY (2021)

Article Physiology

Individual cardiovascular responsiveness to work-matched exercise within the moderate- and severe-intensity domains

Felipe Mattioni Maturana et al.

Summary: Our study demonstrates the significant influence of exercise intensity domains and biological variability on individual V?O-2max response. The proportion of non-responders in MICT was one third of the group, while no non-responders were observed in HIIT. In MICT, there were 11 responders out of 21 participants, compared to 20 responders out of 21 participants in HIIT.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2021)

Article Geriatrics & Gerontology

Effects of Exercise Dose and Detraining Duration on Mobility at Late Midlife: A Randomized Clinical Trial

Tibor Hortobagyi et al.

Summary: The study showed that a moderate volume of exergaming during training produced the most clinically meaningful improvements in mobility and selected cognitive tests in 60-year-old office workers, and these improvements lasted longer after detraining.

GERONTOLOGY (2021)

Article Medicine, General & Internal

Can non-responders be 'rescued' by increasing exercise intensity? A quasi-experimental trial of individual responses among humans living with pre-diabetes or type 2 diabetes mellitus in Canada

Travis J. Hrubeniuk et al.

Summary: This study aims to identify non-responders to aerobic exercise training in individuals living with pre-diabetes or type 2 diabetes and evaluate if increasing training intensity can benefit these non-responders. It will recruit 60 participants for a two-phase aerobic exercise programme, categorize them as responders or non-responders based on HbA1c changes, and then randomly allocate them to maintained intensity or increased intensity training groups.

BMJ OPEN (2021)

Review Nutrition & Dietetics

Possible Effects of Beetroot Supplementation on Physical Performance Through Metabolic, Neuroendocrine, and Antioxidant Mechanisms: A Narrative Review of the Literature

Hamid Arazi et al.

Summary: Beetroot is a valuable source of dietary nutrients and nitrate, which plays a key role in improving athletic performance. It enhances blood circulation, muscle fueling, and possesses antioxidant properties that can help combat inflammatory diseases. Furthermore, the phytochemicals in beetroot can inhibit inflammatory conditions through signaling pathways.

FRONTIERS IN NUTRITION (2021)

Review Cardiac & Cardiovascular Systems

The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever

Fred J. DiMenna et al.

Summary: Regular exercise can lead to chronic adaptations in anatomy/physiology, with a prolonged acute effect on insulin sensitivity lasting up to 72 hours. Individuals with varying levels of insulin sensitivity can benefit from this effect during exercise.

CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM (2021)

Review Biochemistry & Molecular Biology

Exercise, redox system and neurodegenerative diseases

Helong Quan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Biochemistry & Molecular Biology

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs

Debora da Luz Scheffer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Hospitality, Leisure, Sport & Tourism

Exercise immunology: Future directions

David C. Nieman et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

Review Hospitality, Leisure, Sport & Tourism

The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma et al.

JOURNAL OF SPORT AND HEALTH SCIENCE (2020)

Review Pharmacology & Pharmacy

Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium

Melissa A. Luse et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

Review Environmental Sciences

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Madalyn Riley Higgins et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2020)

Article Physiology

Circulating angiogenic cell response to sprint interval and continuous exercise

Louis O'Carroll et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2019)

Review Biochemistry & Molecular Biology

Exercise effects on physiological function during aging

Zsolt Radak et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Sport Sciences

Fruit-Derived Polyphenol Supplementation for Athlete Recovery and Performance

Joanna Bowtell et al.

SPORTS MEDICINE (2019)

Review Endocrinology & Metabolism

Role of exercise-induced hepatokines in metabolic disorders

Gael Ennequin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2019)

Article Cardiac & Cardiovascular Systems

Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise

Anna E. Ramos et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Review Sport Sciences

Cocoa Flavanol Supplementation and Exercise: A Systematic Review

Lieselot Decroix et al.

SPORTS MEDICINE (2018)

Review Medicine, General & Internal

Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease

Bente Klarlund Pedersen

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Physiology

Exercise-modulated epigenetic markers and inflammatory response in COPD individuals: A pilot study

Ivy Reichert Vital da Silva et al.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2017)

Article Biochemistry & Molecular Biology

Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve

Zsolt Radak et al.

REDOX BIOLOGY (2017)

Review Neurosciences

Redox interventions to increase exercise performance

Michael B. Reid

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Review Medicine, Research & Experimental

Epigenetic regulation of skeletal muscle metabolism

Kirsten F. Howlett et al.

CLINICAL SCIENCE (2016)

Review Biochemistry & Molecular Biology

Lactate as a Metabolite and a Regulator in the Central Nervous System

Patrizia Proia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Endocrinology & Metabolism

Ribosome biogenesis adaptation in resistance training-induced human skeletal muscle hypertrophy

Vandre C. Figueiredo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2015)

Article Behavioral Sciences

Acute stress affects the global DNA methylation profile in rat brain: Modulation by physical exercise

Gelson M. Rodrigues et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

Review Physiology

Exercise training and DNA methylation in humans

S. Voisin et al.

ACTA PHYSIOLOGICA (2015)

Review Physiology

Effects of physical activity upon the liver

Roy J. Shephard et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2015)

Article Physiology

Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats

Orsolya Marton et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2015)

Review Biochemistry & Molecular Biology

Can we optimise the exercise training prescription to maximise improvements in mitochondria function and content?

David J. Bishop et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)

Article Biochemistry & Molecular Biology

Polyphenols: Well Beyond The Antioxidant Capacity: Polyphenol Supplementation and Exercise-Induced Oxidative Stress and Inflammation

Antoni Sureda et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2014)

Review Sport Sciences

Exercise: Putting Action into Our Epigenome

Joshua Denham et al.

SPORTS MEDICINE (2014)

Review Biochemistry & Molecular Biology

Redox-regulating sirtuins in aging, caloric restriction, and exercise

Zsolt Radak et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Endocrinology & Metabolism

Acute Metabolic, Hormonal, and Psychological Responses to Different Endurance Training Protocols

P. Wahl et al.

HORMONE AND METABOLIC RESEARCH (2013)

Article Cell Biology

Selectively bred rat model system for low and high response to exercise training

Lauren Gerard Koch et al.

PHYSIOLOGICAL GENOMICS (2013)

Article Physiology

The Influence of Exercise on Cognitive Abilities

Fernando Gomez-Pinilla et al.

COMPREHENSIVE PHYSIOLOGY (2013)

Article Cell Biology

Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle

Romain Barres et al.

CELL METABOLISM (2012)

Article Sport Sciences

Effect of exercise training intensity on murine T-regulatory cells and vaccination response

J. Wang et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2012)

Article Endocrinology & Metabolism

Normal adaptations to exercise despite protection against oxidative stress

Kazuhiko Higashida et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2011)

Review Biochemistry & Molecular Biology

Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA

Zsolt Radak et al.

MOLECULAR ASPECTS OF MEDICINE (2011)

Article Endocrinology & Metabolism

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

Takeshi Yoshizaki et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

Article Endocrinology & Metabolism

The impact of physical exercise on the gastrointestinal tract

Erick Prado de Oliveira et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2009)

Review Cell Biology

Exercise, oxidative stress and hormesis

Zsolt Radak et al.

AGEING RESEARCH REVIEWS (2008)

Article Nutrition & Dietetics

Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance

Mari-Carmen Gomez-Cabrera et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)

Review Biochemistry & Molecular Biology

Systemic adaptation to oxidative challenge induced by regular exercise

Zsolt Radak et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Cell Biology

Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis

S Kuang et al.

JOURNAL OF CELL BIOLOGY (2006)

Article Physiology

Renal handling of salt and water in humans during exercise with or without hydration

JP Mallie et al.

EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2002)

Article Sport Sciences

Individual differences in response to regular physical activity

C Bouchard et al.

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2001)