期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.747789
关键词
miR-181b; translin; trax; microRNA degradation; arterial stiffness; aging
类别
资金
- NIH
- Stimulating and Advancing ACCM Research
- Western Institute
- [U54AG062333]
- [U18TR003780]
- [T32HL007227]
- [DA044123]
Research suggests that microRNA may play a key role in regulating vascular structure and function, potentially impacting arterial stiffness. In particular, inhibiting a specific enzyme involved in microRNA degradation can reverse aging-associated arterial stiffening, offering potential new strategies for combating this condition in the future.
Large artery stiffness (LAS) is a major, independent risk factor underlying cardiovascular disease that increases with aging. The emergence of microRNA signaling as a key regulator of vascular structure and function has stimulated interest in assessing its role in the pathophysiology of LAS. Identification of several microRNAs that display age-associated changes in expression in aorta has focused attention on defining their molecular targets and deciphering their role in age-associated arterial stiffening. Inactivation of the microRNA-degrading enzyme, translin/trax, which reverses the age-dependent decline in miR-181b, confers protection from aging-associated arterial stiffening, suggesting that inhibitors targeting this enzyme may have translational potential. As LAS poses a major public health challenge, we anticipate that future studies based on these advances will yield innovative strategies to combat aging-associated arterial stiffening.
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