期刊
FRONTIERS IN PHYSIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2022.831504
关键词
exercise training; physical activity; cardiopulmonary exercise testing; O-2 uptake; stroke volume; metabolic equivalent; pectus excavatum
类别
This study investigated the influence of physical activity on cardiopulmonary performance and stroke volume in subjects with pectus excavatum (PE). The results showed that physical activity level was a determinant of VO2 max (cardiopulmonary performance), while it did not affect O-2 pulse (stroke volume at peak exercise) in patients with PE.
BackgroundExercise training increases muscle VO2 by increasing O-2 transport and O-2 uptake while cardiac output increase might be limited by the conformation of the chest in subjects with pectus excavatum (PE). AimsThe aim of the present study was to investigate the influence of physical activity (PA) on functional parameters of cardiopulmonary performance and stroke volume obtained at Cardiopulmonary Exercise Test (CPET) in PE. Methods and ProceduresA cohort of adolescents (15 with PE and 15 age- and sex-matched healthy controls, HC) underwent Cardiopulmonary Exercise Test (CPET) and administration of the International Physical Activity Questionnaire - Short Form (IPAQ-SF) with estimation of weekly PA (METs h(-1).week(-1)). Determinants of CPET parameters were investigated with multivariable linear regression analysis. ResultsAs expected, when compared to HC, PE had lower VO2 max (37.2 +/- 6.6 vs. 45.4 +/- 6.4 mL.kg(-1).min(-1), p < 0.05), and VO2/HR max (O-2 pulse, 12.1 +/- 2.4 vs. 16.2 +/- 3.6 mL.min(-1).bpm(-1), p < 0.05). Importantly, physical activity level was a predictor of VO2 max (adjusted for sex, body mass index, FEV1%, and presence of PE, beta = 0.085; 95% Cl 0.010 to 0.160, p = 0.029) whereas O-2 pulse was independent from PA level (beta = 0.035; 95% Cl -0.004 to 0.074). ConclusionPhysical activity is a determinant of VO2 max (cardiopulmonary performance), whereas it appears not to affect O-2 pulse (a measure of stroke volume at peak exercise) related to constrained diastolic filling in PE.
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