4.6 Review

Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Physiology

Serum MMP-3 and its association with central arterial stiffness among young adults is moderated by smoking and BMI

Nathaniel J. Iannarelli et al.

Summary: Central arterial stiffness is independently predicted by higher serum MMP-3 concentrations, which are associated with faster cfPWV and increased arterial stiffness. Interactions between MMP-3 and smoking status, as well as MMP-3 and BMI, may contribute to this association.

PHYSIOLOGICAL REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Association of high-risk coronary atherosclerosis at CCTA with clinical and circulating biomarkers: Insight from CAPIRE study

Edoard Conte et al.

Summary: The study found that inflammatory biomarkers (hs-CRP, PTX3), HbA1c were associated with high-risk plaque features, while male sex and older age were significant predictors of high-risk atherosclerosis.

JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY (2021)

Article Virology

Defining IL-6 levels in healthy individuals: A meta-analysis

Elias A. Said et al.

Summary: This meta-analysis is the first to report IL-6 levels in the blood of healthy donors based on a large number of studies, with a pooled estimate of 5.186 pg/ml. Results showed that IL-6 values increased by 0.05 pg/ml for every 1 year increase in age. Despite heterogeneity, differences in IL-6 values were within a few pg/ml range, possibly due to varying conditions impacting IL-6 production in the healthy population.

JOURNAL OF MEDICAL VIROLOGY (2021)

Review Cell Biology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

Raffaella Di Micco et al.

Summary: Cellular senescence is characterized by permanent proliferation arrest and can occur in response to various stresses like telomere dysfunction. Apart from stress-induced senescence, it can also be part of controlled programs in biological processes like embryonic development. Senescent cells contribute to impaired tissue regeneration, chronic diseases, and organismal aging, but also present an opportunity for intervention in aging and associated diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Biology

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Carmine Izzo et al.

Summary: Oxidative stress is a key factor in aging and age-related diseases, particularly cardiovascular diseases. Aging is a primary risk factor for many diseases, with cardiovascular diseases being a major concern. The focus of research is on the role of oxidative stress in cardiovascular aging and diseases.

LIFE-BASEL (2021)

Article Environmental Sciences

Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome

Agne Satrauskiene et al.

Summary: Four miRs (miR-1, miR-133b, miR-133a, and miR-145) were negatively associated with arterial markers of subclinical atherosclerosis in subjects with metabolic syndrome. Combined, these miRs may have a more substantial diagnostic or prognostic value. Follow-up studies are needed to establish their clinical relevance.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Review Cell Biology

Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies

Hazel J. Shields et al.

Summary: Studies suggest that oxidative damage caused by free radicals can affect lifespan, with ROS levels and oxidative damage inversely correlated with longevity across different species. However, experiments have shown some contradictory results, indicating a complex relationship between ROS and lifespan.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Genetics & Heredity

Regulation of Gene Expression and the Elucidative Role of CRISPR-Based Epigenetic Modifiers and CRISPR-Induced Chromosome Conformational Changes

Andrea Martella et al.

Summary: Gene expression in complex multicellular systems is regulated at multiple stages through transcription and epigenetic mechanisms. The use of CRISPR-Cas9 systems has provided new insights into chromatin dysregulation in genetic diseases, as well as tools for targeted DNA modifications. Future developments are focused on understanding the causal relationship between epigenetic marks, genome organization, and gene regulation.

CRISPR JOURNAL (2021)

Article Cardiac & Cardiovascular Systems

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis

Aikaterini Gatsiou et al.

Summary: The study revealed that miR-34a and miR-34c are associated with coronary artery disease and atherosclerosis in humans, highlighting the clinical significance of miR-34a/b/c in vascular aging and atherosclerotic vascular disease. The mechanistic findings showed that miR-34a and miR-34c control SIRT1 and JAG1, respectively, indicating a role in disease pathogenesis.

ATHEROSCLEROSIS (2021)

Article Cardiac & Cardiovascular Systems

Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome

Gorav Batra et al.

Summary: Elevated IL-6 levels are associated with increased risk of major adverse cardiovascular events in patients with chronic coronary syndrome, particularly in the presence of chronic kidney disease. This suggests that IL-6 and CKD stage could be useful markers for identifying patients who may benefit from anti-inflammatory treatment in the context of chronic coronary syndrome.

JAMA CARDIOLOGY (2021)

Review Cell Biology

Measuring biological aging in humans: A quest

Luigi Ferrucci et al.

AGING CELL (2020)

Article Biochemistry & Molecular Biology

A proteomic atlas of senescence-associated secretomes for aging biomarker development

Nathan Basisty et al.

PLOS BIOLOGY (2020)

Editorial Material Immunology

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

Toshio Hirano et al.

IMMUNITY (2020)

Article Medicine, Research & Experimental

The senescence-associated secretome as an indicator of age and medical risk

Marissa J. Schafer et al.

JCI INSIGHT (2020)

Article Physiology

NOX5: Molecular biology and pathophysiology

Rhian M. Touyz et al.

EXPERIMENTAL PHYSIOLOGY (2019)

Article Medical Laboratory Technology

Effects of blood sample handling procedures on measurable interleukin 6 in plasma and serum

Yan Gong et al.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2019)

Editorial Material Immunology

The nature of human IL-6

Anne Puel et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Editorial Material Genetics & Heredity

Editorial-Role of DNA Methyltransferases in the Epigenome

Albert Jeltsch et al.

Article Biochemistry & Molecular Biology

Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening

Chandrika Canugovi et al.

REDOX BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Article Biotechnology & Applied Microbiology

Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

Wei Wang et al.

DISEASE MARKERS (2019)

Review Cell Biology

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

Ankita Nandi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Review Nutrition & Dietetics

Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?

Thomas Senoner et al.

NUTRIENTS (2019)

Review Pharmacology & Pharmacy

The role of DNA methylation in epigenetics of aging

Archana Unnikrishnan et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Article Biology

Intra-individual methylomics detects the impact of early-life adversity

Shan Jiang et al.

LIFE SCIENCE ALLIANCE (2019)

Article Cell Biology

Plasma proteomic signature of age in healthy humans

Toshiko Tanaka et al.

AGING CELL (2018)

Article Hematology

MicroRNA-Mediated Therapy Modulating Blood-Brain Barrier Disruption Improves Vascular Cognitive Impairment

Kensuke Toyama et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Endocrinology & Metabolism

Endocrine-disrupting chemicals and risk of diabetes: an evidence-based review

P. Monica Lind et al.

DIABETOLOGIA (2018)

Article Medicine, General & Internal

Growth differentiation factor 15 in a community-based sample: age-dependent reference limits and prognostic impact

Steven Doerstling et al.

UPSALA JOURNAL OF MEDICAL SCIENCES (2018)

Review Geriatrics & Gerontology

Oxidative stress, aging, and diseases

Ilaria Liguori et al.

CLINICAL INTERVENTIONS IN AGING (2018)

Review Cell Biology

Telomere Length and All-Cause Mortality: A Meta-analysis

Qi Wang et al.

AGEING RESEARCH REVIEWS (2018)

Article Cardiac & Cardiovascular Systems

Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis The Blood-and-Muscle Model

Athanase Benetos et al.

CIRCULATION RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Mechanisms of Vascular Aging

Zoltan Ungvari et al.

CIRCULATION RESEARCH (2018)

Editorial Material Immunology

Inflammaging INTRODUCTION

Keith L. Kirkwood

IMMUNOLOGICAL INVESTIGATIONS (2018)

Review Physiology

Vascular Oxidative Stress: Impact and Therapeutic Approaches

Cristina M. Sena et al.

FRONTIERS IN PHYSIOLOGY (2018)

Review Pharmacology & Pharmacy

Reactive oxygen species: key regulators in vascular health and diseases

Qishan Chen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Peripheral Vascular Disease

Low Levels of MicroRNA-21 Are a Marker of Reduced Arterial Stiffness in Well-Controlled Hypertension

Fragiskos Parthenakis et al.

JOURNAL OF CLINICAL HYPERTENSION (2017)

Article Peripheral Vascular Disease

Short Telomeres, but Not Telomere Attrition Rates, Are Associated With Carotid Atherosclerosis

Simon Toupance et al.

HYPERTENSION (2017)

Article Peripheral Vascular Disease

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

Tomasz J. Guzik et al.

HYPERTENSION (2017)

Article Peripheral Vascular Disease

The relationship between soluble CD40 ligand level and atherosclerosis in white-coat hypertension

Yu-qing Huang et al.

JOURNAL OF HUMAN HYPERTENSION (2017)

Article Medicine, Research & Experimental

Stability of pro- and anti-inflammatory immune biomarkers for human cohort studies

C. Graham et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Article Medicine, General & Internal

Oxidative Stress and Hypertensive Diseases

Roxana Loperena et al.

MEDICAL CLINICS OF NORTH AMERICA (2017)

Review Pharmacology & Pharmacy

C-reactive protein and ageing

Ying Tang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

Sandra Freitas-Rodriguez et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2017)

Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

Article Geriatrics & Gerontology

Association between GDF-15 levels and changes in vascular and physical function in older patients with hypertension

Maryam Barma et al.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2017)

Review Medicine, General & Internal

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

Claudio de Lucia et al.

FRONTIERS IN MEDICINE (2017)

Article Peripheral Vascular Disease

Inflammation and Arterial Stiffness in Chronic Kidney Disease: Findings From the CRIC Study

Eliot Peyster et al.

AMERICAN JOURNAL OF HYPERTENSION (2017)

Review Biochemistry & Molecular Biology

Senescence in Health and Disease

Shenghui He et al.

Article Cardiac & Cardiovascular Systems

Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis

Yunwei Li et al.

ATHEROSCLEROSIS (2017)

Review Peripheral Vascular Disease

Early Vascular Ageing (EVA): Definitions and Clinical Applicability

Pedro G. Cunha et al.

CURRENT HYPERTENSION REVIEWS (2017)

Article Biochemical Research Methods

Normalization of circulating microRNA expression data obtained by quantitative real-time RT-PCR

Francesco Marabita et al.

BRIEFINGS IN BIOINFORMATICS (2016)

Review Cardiac & Cardiovascular Systems

Vascular age to determine cardiovascular disease risk: A systematic review of its concepts, definitions, and clinical applications

K. A. Groenewegen et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

Rokas Navickas et al.

CARDIOVASCULAR RESEARCH (2016)

Review Geriatrics & Gerontology

Secreted growth differentiation factor15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

Yasunori Fujita et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2016)

Article Cardiac & Cardiovascular Systems

MicroRNAs relate to early worsening of renal function in patients with acute heart failure

Noemi Bruno et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Article Peripheral Vascular Disease

Predictors of Carotid Intima-Media Thickness and Plaque Progression in a Chinese Population

Ling-Chun Huang et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2016)

Article Cardiac & Cardiovascular Systems

Circulating microRNAs predict future fatal myocardial infarction in healthy individuals - The HUNT study

Anja Bye et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Article Cardiac & Cardiovascular Systems

Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution

Rugmani Padmanabhan Iyer et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2016)

Review Biotechnology & Applied Microbiology

Function, Role, and Clinical Application of MicroRNAs in Vascular Aging

Xiao Lin et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Geriatrics & Gerontology

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

Monika Puzianowska-Kuznicka et al.

IMMUNITY & AGEING (2016)

Review Pharmacology & Pharmacy

An overview of microRNAs

Scott M. Hammond

ADVANCED DRUG DELIVERY REVIEWS (2015)

Review Cell Biology

DNA methylation and healthy human aging

Meaghan J. Jones et al.

AGING CELL (2015)

Article Genetics & Heredity

The DNA methylation drift of the atherosclerotic aorta increases with lesion progression

Maria del Pilar Valencia-Morales et al.

BMC MEDICAL GENOMICS (2015)

Article Pharmacology & Pharmacy

Circulating miR-21 and eNOS in subclinical atherosclerosis in patients with hypertension

Mahir Cengiz et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2015)

Review Medical Laboratory Technology

Data Normalization Strategies for MicroRNA Quantification

Heidi Schwarzenbach et al.

CLINICAL CHEMISTRY (2015)

Review Cardiac & Cardiovascular Systems

Novel methodologies for biomarker discovery in atherosclerosis

Imo E. Hoefer et al.

EUROPEAN HEART JOURNAL (2015)

Article Biochemistry & Molecular Biology

Normalization panels for the reliable quantification of circulating microRNAs by RT-qPCR

Maayke G. M. Kok et al.

FASEB JOURNAL (2015)

Review Cardiac & Cardiovascular Systems

Cellular and molecular biology of aging endothelial cells

Anthony J. Donato et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Multidisciplinary Sciences

Function and information content of DNA methylation

Dirk Schuebeler

NATURE (2015)

Review Nursing

Reactive Oxygen and Nitrogen Species Impact on Endothelial Dysfunction

Dereck Salisbury et al.

NURSING RESEARCH (2015)

Article Cardiac & Cardiovascular Systems

Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes Systematic Review and Meta-Analysis

Matthew J. J. D'Mello et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2015)

Review Cell Biology

MicroRNAs in vascular aging and atherosclerosis

Rossella Menghini et al.

AGEING RESEARCH REVIEWS (2014)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Augusto C. Montezano et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Cardiac & Cardiovascular Systems

A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy

Benjamin Meder et al.

EUROPEAN HEART JOURNAL (2014)

Article Cardiac & Cardiovascular Systems

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

Stephen Kaptoge et al.

EUROPEAN HEART JOURNAL (2014)

Article Biochemical Research Methods

Rapid determination of il-6 specific activity by flow cytometry

Carl Simard et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2014)

Article Biochemistry & Molecular Biology

Increased Hs-CRP/adiponectin ratio is associated with increase carotid intima-media thickness

Huocheng Liao et al.

LIPIDS IN HEALTH AND DISEASE (2014)

Review Endocrinology & Metabolism

Proinflammation: the key to arterial aging

Mingyi Wang et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2014)

Article Medicine, General & Internal

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

Philip C. Haycock et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Review Biotechnology & Applied Microbiology

The Role of Oxidative Stress and Inflammation in Cardiovascular Aging

Junzhen Wu et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Cell Biology

MicroRNAs Regulate Vascular Medial Calcification

Jane Leopold

Review Cell Biology

A systematic review of leukocyte telomere length and age in adults

Aysel Mueezzinler et al.

AGEING RESEARCH REVIEWS (2013)

Article Cell Biology

Age-related changes in microRNA levels in serum

Nicole Noren Hooten et al.

AGING-US (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Biochemistry & Molecular Biology

The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1

Klaus Unsicker et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

Review Cardiac & Cardiovascular Systems

High-Sensitivity C-Reactive Protein and Cardiovascular Disease A Resolute Belief or an Elusive Link?

Omair Yousuf et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2013)

Article Medicine, Research & Experimental

Plasma microRNA-133a is a new marker for both acute myocardial infarction and underlying coronary artery stenosis

Feng Wang et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2013)

Article Geriatrics & Gerontology

Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells

Zoltan Ungvari et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

Article Biochemistry & Molecular Biology

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

Gregory Hannum et al.

MOLECULAR CELL (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Review Cardiac & Cardiovascular Systems

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

Bernard Lassegue et al.

CIRCULATION RESEARCH (2012)

Article Pharmacology & Pharmacy

Elevated Levels of MMP-9 in Untreated Patients with Stage I Essential Hypertension

Eugenia Gkaliagkousi et al.

CLINICAL AND EXPERIMENTAL HYPERTENSION (2012)

Article Cardiac & Cardiovascular Systems

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

Joep Perk et al.

TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY (2012)

Article Medicine, Research & Experimental

Evidence of Increased Oxidative Stress in Aged Mesenteric Lymphatic Vessels

Sangeetha Thangaswamy et al.

LYMPHATIC RESEARCH AND BIOLOGY (2012)

Review Genetics & Heredity

MicroRNA profiling: approaches and considerations

Colin C. Pritchard et al.

NATURE REVIEWS GENETICS (2012)

Review Cardiac & Cardiovascular Systems

European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)

Joep Perk et al.

EUROPEAN HEART JOURNAL (2012)

Review Cell Biology

Inflammatory markers in population studies of aging

Tushar Singh et al.

AGEING RESEARCH REVIEWS (2011)

Review Cardiac & Cardiovascular Systems

Cellular Senescence, Vascular Disease, and Aging Part 1 of a 2-Part Review

Jason C. Kovacic et al.

CIRCULATION (2011)

Article Cardiac & Cardiovascular Systems

Quantification of Coronary Atherosclerosis and Inflammation to Predict Coronary Events and All-Cause Mortality

Stefan Moehlenkamp et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2011)

Article Biochemistry & Molecular Biology

Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR

Abraham Aviv et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Hematology

Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk

Peter Willeit et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Hematology

Relations of Biomarkers of Extracellular Matrix Remodeling to Incident Cardiovascular Events and Mortality

Raghava S. Velagaleti et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Cardiac & Cardiovascular Systems

Leukocyte telomere length is associated with measures of subclinical atherosclerosis

A. G. Panayiotou et al.

ATHEROSCLEROSIS (2010)

Review Biotechnology & Applied Microbiology

Normalization strategies for microRNA profiling experiments: a 'normal' way to a hidden layer of complexity?

Swanhild U. Meyer et al.

BIOTECHNOLOGY LETTERS (2010)

Article Cardiac & Cardiovascular Systems

Proteomic Strategies in the Search of New Biomarkers in Atherothrombosis

Jose Tunon et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2010)

Review Oncology

The regulatory crosstalk between kinases and proteases in cancer

Carlos Lopez-Otin et al.

NATURE REVIEWS CANCER (2010)

Article Cardiac & Cardiovascular Systems

MMP-1 serum levels predict coronary atherosclerosis in humans

Michael Lehrke et al.

CARDIOVASCULAR DIABETOLOGY (2009)

Review Immunology

Biomarkers of human immunosenescence: impact of Cytomegalovirus infection

Evelyna Derhovanessian et al.

CURRENT OPINION IN IMMUNOLOGY (2009)

Article Cardiac & Cardiovascular Systems

Systemic telomere length and preclinical atherosclerosis: the Asklepios Study

Tim De Meyer et al.

EUROPEAN HEART JOURNAL (2009)

Article Geriatrics & Gerontology

Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

Jeremy D. Walston et al.

EXPERIMENTAL GERONTOLOGY (2009)

Review Peripheral Vascular Disease

Vascular Aging A Tale of EVA and ADAM in Cardiovascular Risk Assessment and Prevention

Peter M. Nilsson et al.

HYPERTENSION (2009)

Article Peripheral Vascular Disease

Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells

Tongrong He et al.

MICROVASCULAR RESEARCH (2009)

Review Medicine, General & Internal

The connection between C-reactive protein and atherosclerosis

Sanjay K. Singh et al.

ANNALS OF MEDICINE (2008)

Review Biochemistry & Molecular Biology

Advances in assays of matrix metalloproteinases (MMPs) and their inhibitors

Xian-Chao Cheng et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2008)

Review Peripheral Vascular Disease

The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome

Peter M. Nilsson et al.

JOURNAL OF HYPERTENSION (2008)

Article Biochemistry & Molecular Biology

p53-repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation

Ran Brosh et al.

MOLECULAR SYSTEMS BIOLOGY (2008)

Article Peripheral Vascular Disease

C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community

H. R. Nakhai-Pour et al.

JOURNAL OF HUMAN HYPERTENSION (2007)

Review Biochemistry & Molecular Biology

Telomere length, stem cells and aging

Maria A. Blasco

NATURE CHEMICAL BIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure

Tibor Kempf et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2007)

Article Cardiac & Cardiovascular Systems

Effects of age on plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs)

D. Dirk Bonnema et al.

JOURNAL OF CARDIAC FAILURE (2007)

Review Biology

Pathophysiological significance of adiponectin

Makoto Nishida et al.

MEDICAL MOLECULAR MORPHOLOGY (2007)

Review Peripheral Vascular Disease

Central arterial aging and the epidemic of systolic hypertension and atherosclerosis

Edward G. Lakatta

JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION (2007)

Article Cardiac & Cardiovascular Systems

Effects of angiotensin II receptor blockade with valsartan on pro-inflammatory cytokines in patients with essential hypertension

S Manabe et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2005)

Review Cell Biology

The telomere length dynamic and methods of its assessment

KW Lin et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2005)

Review Genetics & Heredity

Telomeres and human disease: Ageing, cancer and beyond

MA Blasco

NATURE REVIEWS GENETICS (2005)

Article Peripheral Vascular Disease

Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjects

G Vázquez-Oliva et al.

JOURNAL OF HUMAN HYPERTENSION (2005)

Article Peripheral Vascular Disease

Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta

M McNulty et al.

AMERICAN JOURNAL OF HYPERTENSION (2005)

Article Urology & Nephrology

Plasma interleukin-6 predicts cardiovascular mortality in hemodialysis patients

M Rao et al.

AMERICAN JOURNAL OF KIDNEY DISEASES (2005)

Article Cardiac & Cardiovascular Systems

Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media

MG Ferrini et al.

CARDIOVASCULAR RESEARCH (2004)

Article Multidisciplinary Sciences

The functions of animal microRNAs

V Ambros

NATURE (2004)

Article Medicine, General & Internal

Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease

S Blankenberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

Review Biochemistry & Molecular Biology

Assessment of telomere length and factors that contribute to its stability

SN Saldanha et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Telomere measurement by quantitative PCR

RM Cawthon

NUCLEIC ACIDS RESEARCH (2002)

Article Cardiac & Cardiovascular Systems

Inflammation and atherosclerosis

P Libby et al.

CIRCULATION (2002)

Review Rheumatology

The paradigm of IL-6: from basic science to medicine

Tetsuji Naka et al.

ARTHRITIS RESEARCH & THERAPY (2002)

Review Biochemistry & Molecular Biology

Switching and signaling at the telomere

EH Blackburn

Article Biochemistry & Molecular Biology

Aging Exacerbates Hydrogen Peroxide-Induced Alteration of Vascular Reactivity in Rats

S. Tanguy et al.

ANTIOXIDANTS & REDOX SIGNALING (2000)