相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Deubiquitylases in developmental ubiquitin signaling and congenital diseases
Mohammed A. Basar et al.
CELL DEATH AND DIFFERENTIATION (2021)
Botulinum Toxin: An Update on Pharmacology and Newer Products in Development
Supriyo Choudhury et al.
TOXINS (2021)
The deubiquitylase USP9X controls ribosomal stalling (vol 220, e202004211, 2021)
Anne Clancy et al.
JOURNAL OF CELL BIOLOGY (2021)
Botulinum neurotoxin inhibitor binding dynamics and kinetics relevant for drug design
Kruti B. Patel et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)
Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases
Xue Bai et al.
BIOMEDICINE & PHARMACOTHERAPY (2021)
Identification and validation of selective deubiquitinase inhibitors
Anthony C. Varca et al.
CELL CHEMICAL BIOLOGY (2021)
Small molecules as tools for functional assessment of deubiquitinating enzyme function
Robert S. Magin et al.
CELL CHEMICAL BIOLOGY (2021)
Small molecules that target the ubiquitin system
Hai Qiu Wu et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2020)
Symptomatic treatment of botulism with a clinically approved small molecule
Edwin Vazquez-Cintron et al.
JCI INSIGHT (2020)
Breaking the chains: deubiquitylating enzyme specificity begets function
Michael J. Clague et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule
Lucy Lin et al.
ACCOUNTS OF CHEMICAL RESEARCH (2019)
Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches
Christine Rasetti-Escargueil et al.
TOXINS (2019)
The Deubiquitinating Enzyme Inhibitor PR-619 Enhances the Cytotoxicity of Cisplatin via the Suppression of Anti-Apoptotic Bcl-2 Protein: In Vitro and In Vivo Study
Kuan-Lin Kuo et al.
CELLS (2019)
Celastrol-induced degradation of FANCD2 sensitizes pediatric high-grade gliomas to the DNA-crosslinking agent carboplatin
Dennis S. Metselaar et al.
EBIOMEDICINE (2019)
Deubiquitylating enzymes and drug discovery: emerging opportunities
Jeanine A. Harrigan et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model
Jelena Konstantinovic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
A Mechanistic Overview of Triptolide and Celastrol, Natural Products from Tripterygium wilfordii Hook F
Shao-Ru Chen et al.
FRONTIERS IN PHARMACOLOGY (2018)
Principles of Ubiquitin-Dependent Signaling
Eugene Oh et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 (2018)
Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells
Xiaoli Li et al.
ONCOTARGETS AND THERAPY (2018)
Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance
Nagarajan Thirunavukkarasu et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)
Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays
Paul T. Bremer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A
Paul T. Bremer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication
Yien Che Tsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα
Katrin Schweitzer et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)
Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth
Bo Yang et al.
ONCOTARGET (2016)
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
Ling Nan et al.
SCIENTIFIC REPORTS (2016)
Control of autoimmune inflammation by celastrol, a natural triterpenoid
Shivaprasad H. Venkatesha et al.
PATHOGENS AND DISEASE (2016)
Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents
Gui-Zhen Wang et al.
CANCER SCIENCE (2015)
Src Family Kinase Inhibitors Antagonize the Toxicity of Multiple Serotypes of Botulinum Neurotoxin in Human Embryonic Stem Cell-Derived Motor Neurons
Erkan Kiris et al.
NEUROTOXICITY RESEARCH (2015)
Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing
Phillip H. Beske et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2015)
A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins
Domenico Azarnia Tehran et al.
SCIENTIFIC REPORTS (2015)
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays
Erkan Kiris et al.
PLOS ONE (2015)
High-Throughput Viability Assay Using an Autonomously Bioluminescent Cell Line with a Bacterial Lux Reporter
Bradley Class et al.
JALA (2015)
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance
Ze Tian et al.
BLOOD (2014)
Recent Advances in Botulinum Neurotoxin Inhibitor Development
Erkan Kiris et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2014)
Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery
Erkan Kiris et al.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2014)
Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria
Milica Videnovic et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer
Shan Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities
Vivien Landre et al.
ONCOTARGET (2014)
A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors
Krishna P. Kota et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)
Characterization of Selective Ubiquitin and Ubiquitin-Like Protease Inhibitors Using a Fluorescence-Based Multiplex Assay Format
Xufan Tian et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2011)
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
Vaibhav Kapuria et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
Mikael Altun et al.
CHEMISTRY & BIOLOGY (2011)
Inhibition of proteasome deubiquitinating activity as a new cancer therapy
Padraig D'Arcy et al.
NATURE MEDICINE (2011)
Accelerated Neuronal Cell Recovery from Botulinum Neurotoxin Intoxication by Targeted Ubiquitination
Chueh-Ling Kuo et al.
PLOS ONE (2011)
Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery
Erkan Kiris et al.
STEM CELL RESEARCH (2011)
A Cell-Based High-Throughput Assay for the Screening of Small-Molecule Inhibitors of p53-MDM2 Interaction
Jing Li et al.
JOURNAL OF BIOMOLECULAR SCREENING (2011)
Botulinum Neurotoxin: A Marvel of Protein Design
Mauricio Montal
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79 (2010)
Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
Vaibhav Kapuria et al.
CANCER RESEARCH (2010)
Targeting botulinum neurotoxin persistence by the ubiquitin-proteasome system
Yien Che Tsai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Zinc-Dependent Protease Activity of the Botulinum Neurotoxins
Frank J. Lebeda et al.
TOXINS (2010)
Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
Benjamin Nicholson et al.
PROTEIN SCIENCE (2008)
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Yili Yang et al.
CANCER RESEARCH (2007)
Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis
Emanuela Aleo et al.
CANCER RESEARCH (2006)
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy
Yipin Lu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Uptake of botulinum neurotoxin into cultured neurons
JE Keller et al.
BIOCHEMISTRY (2004)
The role of the synaptic protein SNAP-25 in the potency of botulinum neurotoxin type A
JE Keller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Botulinum toxin as a biological weapon - Medical and public health management
SS Arnon et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2001)
分享论文
