4.7 Review

Approaches to Decrease Hyperglycemia by Targeting Impaired Hepatic Glucose Homeostasis Using Medicinal Plants

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

PTP1B and α-glucosidase inhibitors from Selaginella rolandi-principis and their glucose uptake stimulation

Dinh-Tuan Nguyen et al.

Summary: A new coumarin and four known isoflavones were isolated from a Vietnamese medicinal plant, exhibiting potential antidiabetic properties, which opens up possibilities for further research and development of new natural inhibitors for diabetes.

JOURNAL OF NATURAL MEDICINES (2021)

Article Integrative & Complementary Medicine

Integration of network and experimental pharmacology to decipher the antidiabetic action of Duranta repens L.

Pukar Khanal et al.

Summary: This study evaluated the effects of Duranta repens on diabetes mellitus using network pharmacology approach, revealing its potential regulation of the PI3K-Akt signaling pathway and PTP1B protein to enhance glucose uptake, insulin production, glycolysis, and decrease gluconeogenesis.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2021)

Article Endocrinology & Metabolism

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2021

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provides clinical practice recommendations, treatment goals, guidelines, and tools for evaluating care quality. It is updated annually by a multidisciplinary expert committee, and readers are invited to comment on the standards at professional.diabetes.org/SOC.

DIABETES CARE (2021)

Article Integrative & Complementary Medicine

Hypoglycemic Effect of Calea urticifolia (Mill.) DC.

Adolfo Andrade-Cetto et al.

Summary: The traditional use of Calea urticifolia in Mexico to treat type 2 diabetes has been found to produce a significant hypoglycemic effect in rodents. This effect may be achieved by reducing glucose synthesis and slightly inhibiting glucose absorption, as demonstrated by glucose tolerance tests and biochemical analyses.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2021)

Review Nutrition & Dietetics

Regulation of Postabsorptive and Postprandial Glucose Metabolism by Insulin-Dependent and Insulin-Independent Mechanisms: An Integrative Approach

George D. Dimitriadis et al.

Summary: Glucose homeostasis is regulated by insulin, with key roles played by the liver, kidneys, skeletal muscle, and adipose tissue. Insulin resistance during sleep helps maintain normal blood glucose levels by switching to fatty acid oxidation in muscles and modulating glucose production from the liver and kidneys. Postprandial glucose fluctuations are optimally regulated by a combination of various mechanisms, including the liver's critical role in disposing ingested glucose and preventing acute increases in blood glucose levels after meals.

NUTRIENTS (2021)

Article Plant Sciences

Contribution of fasting and postprandial glucose-lowering mechanisms to the acute hypoglycemic effect of traditionally used Eryngium cymosum F. Delaroche

Fernanda Espinoza-Hernandez et al.

Summary: The aqueous extract of Eryngium cymosum has a significant hypoglycemic effect in hyperglycaemic rats by reducing blood glucose levels and inhibiting gluconeogenic enzymes activity, while also affecting insulin levels. Therefore, E. cymosum may have potential effectiveness in treating type 2 diabetes.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

Aloe vera carbohydrates regulate glucose metabolism through improved glycogen synthesis and downregulation of hepatic gluconeogenesis in diabetic rats

Swaminathan Govindarajan et al.

Summary: The study investigated the antidiabetic mechanism of Aloe vera carbohydrate fraction (AVCF) and found that AVCF can improve glucose metabolism by promoting insulin secretion, reducing inflammation, and regulating glucose metabolism enzymes, thereby maintaining glucose homeostasis. The results suggest that AVCF may serve as an alternative medicine for alleviating symptoms of diabetes mellitus.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

Launaea acanthodes (Boiss) O. Kuntze mediates hepatic glucose metabolism and ameliorates impaired pancreatic function in streptozotocin-induced diabetic rats

Mohsen Marvibaigi et al.

Summary: The hydroalcoholic extract of Launaea acanthodes demonstrated potential radical scavenging activity and high levels of phenolic and flavonoid content. In vivo studies showed that the extract effectively lowered fasting blood glucose levels, increased body weight, restored altered food and water intake, improved lipid profiles, and ameliorated OGTT results in diabetic rats. Additionally, the extract improved histopathological changes in the pancreas, reduced oxidative stress markers, and reinstated levels of key liver enzymes in diabetic rats. Analysis of gene expression data revealed that the extract regulated glucose metabolism enzymes and pancreatic function, showing its hypoglycemic effects through antioxidant properties.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Plant Sciences

Astragaloside IV inhibits protein tyrosine phosphatase 1B and improves insulin resistance in insulin-resistant HepG2 cells and triglyceride accumulation in oleic acid (OA)-treated HepG2 cells

Xiao Zhou et al.

Summary: The study demonstrated that AST IV effectively improved insulin resistance in HepG2 cells and reduced triglyceride accumulation in OA-treated HepG2 cells by inhibiting PTP1B.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Water Extract of Mungbean (Vigna radiata L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells

Orathai Saeting et al.

Summary: The study demonstrated that mungbean water extract increased cellular glucose uptake and improved insulin sensitivity of insulin-resistant HepG2 cells by inhibiting PTP-1B and modulating the expression of genes related to glucose metabolism. This suggests that mungbean water extract has the potential to be a functional ingredient for diabetes.

MOLECULES (2021)

Review Biotechnology & Applied Microbiology

Natural products in drug discovery: advances and opportunities

Atanas G. Atanasov et al.

Summary: Natural products and their analogues have historically played a significant role in pharmacotherapy, however, they also present challenges. Recent technological and scientific developments are addressing these challenges and revitalizing interest in natural products as drug leads, particularly for combating antimicrobial resistance.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Spectroscopy

Characteristics of the interaction mechanisms of procyanidin B1 and procyanidin B2 with protein tyrosine phosphatase-1B: Analysis by kinetics, spectroscopy methods and molecular docking

Bin Li et al.

Summary: Procyanidins PB1 and PB2 inhibit the activity of PTP1B in a mixed inhibition mode, leading to decreased enzyme activity and altered secondary structure. Hydrophobic interactions play a key role in the binding of procyanidins with PTP1B.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

Article Chemistry, Analytical

Ligand fishing based on cell surface display of enzymes for inhibitor screening

Yun-Cong Yuan et al.

Summary: The study demonstrates for the first time the use of ligand fishing with baits prepared by displaying enzymes on cell surfaces to screen for enzyme inhibitors from complex chemical systems. The displayed PTP1B showed good enzymatic activity and stability, and successfully fished out arbutin as an inhibitor from Rhodiola rosea extracts. This ligand fishing technique using recombinant cells as baits provides a new avenue for accurate and specific screening of active compounds from natural products.

ANALYTICA CHIMICA ACTA (2021)

Review Medicine, Research & Experimental

Adipose tissue and insulin resistance in obese

Bulbul Ahmed et al.

Summary: This review discusses the potential mechanisms behind obesity-associated insulin resistance, such as dysfunctional adipose tissue, excessive release of free fatty acids, and the impact of lipotoxicity on cellular dysfunction leading to systemic inflammation and disruption of the insulin signaling pathway. It highlights that hepatic insulin resistance is the primary event that triggers peripheral tissue insulin resistance.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

Carbazole alkaloids from the fruits of Clausena anisum-olens with potential PTP1B and α-glucosidase inhibitory activities

Yan-Ping Liu et al.

Summary: The phytochemical investigation on the fruits of Clausena anisum-olens resulted in the isolation of 18 carbazole alkaloids, including both new and known compounds. These compounds showed significant inhibitory activities against PTP1B and alpha-glucosidase, suggesting their potential in developing new treatments for diabetes mellitus.

BIOORGANIC CHEMISTRY (2021)

Article Plant Sciences

Hypoglycemic Effect of Two Mexican Medicinal Plants

Adolfo Andrade-Cetto et al.

Summary: This study confirmed the traditional use of E. longifolium and A. firma as hypoglycemic agents in a hyperglycemic animal model for the first time. Both plants exhibited a significant hypoglycemic effect and inhibited enzymes involved in glucose metabolism in vitro.

PLANTS-BASEL (2021)

Review Medicine, General & Internal

PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews

Matthew J. Page et al.

Summary: The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess trustworthiness. PRISMA 2020 aims to improve the transparency and completeness of systematic review reporting, in hopes of guiding more accurate and transparent reporting.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Biology

Ameliorative property of Sesbania grandiflora on carbohydrate metabolic enzymes in the liver and kidney of streptozotocin-induced diabetic rats

Chandrabose Sureka et al.

Summary: The study showed that Sesbania grandiflora flower extract has anti-hyperglycemic effects in diabetic rats, improving insulin secretion and reducing glucose levels, while also regulating glycogen and carbohydrate metabolic enzyme activities.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Cell Biology

Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway

Anna Kowalczuk et al.

Summary: The study demonstrates that calystegines from Hyoscyamus albus provide cytoprotection to HepG2 cells against insulin/glucose induced insulin resistance and apoptosis by regulating SIRT1/Foxo1/G6PC/mTOR and NF-kappaB/JNK/TLR4 signaling pathways.

CELL COMMUNICATION AND SIGNALING (2021)

Article Chemistry, Applied

Screening and tissue distribution of protein tyrosine phosphatase 1B inhibitors in mice following oral administration of Garcinia mangostana L. ethanolic extract

Yu Hu et al.

Summary: In this study, six xanthones from mangosteen were found to inhibit the activity of PTP1B, with garcinone E being the most effective inhibitor. These compounds were distributed in eleven tissues, and mangosteen could be a promising source of natural compounds with high PTP1B inhibitory activity.

FOOD CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

On the Inhibitability of Natural Products Isolated from Tetradium ruticarpum towards Tyrosine Phosphatase 1B (PTP1B) and α-Glucosidase (3W37): An In Vitro and In Silico Study

Dao-Cuong To et al.

Summary: Folk experiences suggest natural products in Tetradium ruticarpum can be effective inhibitors towards diabetes-related enzymes. Experimental studies isolate two natural products which demonstrate high potential in inhibiting PTP1B and alpha-glucosidase, suggesting potential alternatives for diabetes treatment. Computational methods confirm the stability of the ligands and their interaction with targeted proteins, correlating with experimental results.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Meroterpenoids from the leaves of Psidium guajava (guava) cultivated in Korea using MS/MS-based molecular networking

Byeol Ryu et al.

Summary: MS/MS-based molecular networking revealed differences in chemical profiles of Psidium guajava grown in Jeju Island, Vietnam, and China, particularly in the terpenoid-coupled-phloroglucinol clusters. A chemical investigation of the 95% EtOH extract of Jejuguava leaves led to the discovery of new meroterpenoids named jejuguajavones A-J, with some compounds exhibiting inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) enzyme.

PHYTOCHEMISTRY (2021)

Article Multidisciplinary Sciences

The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model

Lisa Ilobekemen Ekakitie et al.

Summary: The study demonstrates that the aqueous extract of C. orbicularis leaf significantly reduced fasting blood glucose and MDA levels, as well as decreased glucose-6-phosphatase activity in diabetic rats. Additionally, administration of C. orbicularis leaf extract to diabetic rats showed a significant increase in liver glycogen level, antioxidant enzyme activities, and glucose transporters levels. This suggests that C. orbicularis leaf extract may have beneficial effects in managing diabetes mellitus and its secondary effects.

HELIYON (2021)

Article Chemistry, Applied

Puerarin as a Potential Drug Candidate for the Management of Type-2 Diabetes: Molecular Docking and Pharmacophore Modeling Studies

Oluwafemi Adeleke Oji

Summary: The study evaluated the molecular interactions between Puerarin and various receptors related to type-2 diabetes, showing that Puerarin is a potent inhibitor that binds well with these receptors. This suggests the potential for developing Puerarin as a more effective alternative for current diabetic management.

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Carbazole alkaloids from the fruits of Clausena anisum-olens with potential PTP1B and ?-glucosidase inhibitory activities

Yan-Ping Liu et al.

Summary: A total of 18 carbazole alkaloids were isolated from the fruits of Clausena anisum-olens, including three new ones and 12 known analogues. These compounds exhibited significant protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase inhibitory activities, which may be promising for the treatment of diabetes mellitus.

BIOORGANIC CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis

Guang-Zhen Lang et al.

BIOORGANIC CHEMISTRY (2020)

Article Pharmacology & Pharmacy

Hepatic Glucose Output Inhibition by Mexican Plants Used in the Treatment of Type 2 Diabetes

Gerardo Mata-Torres et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Agriculture, Multidisciplinary

Antioxidant and Antidiabetic Activities of Flavonoid Derivatives from the Outer Skins of Allium cepa L.

Ngoc Khanh Vu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Agriculture, Multidisciplinary

Novel Protein Tyrosine Phosphatase 1B Inhibitor-Geranylated Flavonoid from Mulberry Leaves Ameliorates Insulin Resistance

Sheng-Li Niu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Flavonoids and Terpenoids with PTP-1B Inhibitory Properties from the Infusion of Salvia amarissima Ortega

Eric Salinas-Arellano et al.

MOLECULES (2020)

Article Integrative & Complementary Medicine

Docking Studies on Potential Mechanisms for Decreasing Insulin Resistance by the Tangzhiqing Herbal Formula

Jia Hao et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2020)

Review Food Science & Technology

Natural products: Regulating glucose metabolism and improving insulin resistance

Fatma S. A. Saadeldeen et al.

FOOD SCIENCE AND HUMAN WELLNESS (2020)

Article Medicine, Research & Experimental

Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic syndrome in C57BL/6J mice fed with high-fat diet

Feng Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

Novel oligomeric neolignans with PTP1B inhibitory activity from the bark of Magnolia officinalis var. biloba

Chuan Li et al.

BIOORGANIC CHEMISTRY (2020)

Article Plant Sciences

3α,19-Dihydroxyl-ent-pimara-8(14),15-diene, a new diterpenoid from the rhizomes of Ricinus communis

Sheng-Nan Zhang et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019)

Article Medicine, Research & Experimental

Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice

Ying Guo et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Plant Sciences

Multi-target antidiabetic mechanisms of mexicanolides from Swietenia humilis

Berenice Ovalle-Magallanes et al.

PHYTOMEDICINE (2019)

Article Medicine, Research & Experimental

Regulating role of ethyl acetate fraction of Tephrosia tinctoria pers. in carbohydrate metabolism and oxidative stress in diabetic rats

Rajaram Krishnasamy et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Biochemistry & Molecular Biology

Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba

Chuan Li et al.

BIOORGANIC CHEMISTRY (2019)

Article Agriculture, Multidisciplinary

Antidiabetic Stilbenes from Peony Seeds with PTP1B, α-Glucosidase, and DPPIV Inhibitory Activities

Chen-Chen Zhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Agriculture, Multidisciplinary

Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor

Jin-Long Tian et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)

Article Plant Sciences

Protein Tyrosine Phosphatase 1B Inhibitory iridoids from Psydrax subcordata

Junfei Zhou et al.

JOURNAL OF NATURAL PRODUCTS (2019)

Article Plant Sciences

Psiguadiols A-J, Rearranged Meroterpenoids as Potent PTP1B Inhibitors from Psidium guajava

Ji-Qin Hou et al.

JOURNAL OF NATURAL PRODUCTS (2019)

Article Chemistry, Analytical

Chemical and Pharmacological Evaluation of Hulls of Prunus dulcis Nuts

Muhammad Nasimullah Qureshi et al.

INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY (2019)

Article Medicine, Research & Experimental

Phytomodulatory proteins promote inhibition of hepatic glucose production and favor glycemic control via the AMPK pathway

Keciany Alves de Oliveira et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Chemistry, Medicinal

Acetophenone derivatives from the roots of Melicope ptelefolia

Qi-Qi Xu et al.

FITOTERAPIA (2019)

Article Biochemistry & Molecular Biology

Lignans from the Twigs of Litsea cubeba and Their Bioactivities

Xiuting Li et al.

MOLECULES (2019)

Article Biology

Phytotherapeutic efficacy of the medicinal plant Terminalia catappa L.

Natarajan Divya et al.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2019)

Article Integrative & Complementary Medicine

Protein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubus chingii

Zhang Xiang-Yu et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2019)

Article Medicine, Research & Experimental

Qing Gan Zi Shen Tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat

Yao Zhu et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Biochemical Research Methods

Serum metabonomics study on antidiabetic effects of fenugreek flavonoids in streptozotocin-induced rats

Wenyue Jiang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2018)

Article Pharmacology & Pharmacy

Anti-diabetic effect and mechanism of Kursi Wufarikun Ziyabit in L6 rat skeletal muscle cells

Salamet Edirs et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)

Review Pharmacology & Pharmacy

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

Lina Xu et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Chemistry, Medicinal

Inhibition of metabolic disorders in vivo and in vitro by main constituent of Coreopsis tinctoria

Bao-Ping Jiang et al.

CHINESE HERBAL MEDICINES (2018)

Article Chemistry, Medicinal

New neo-lignan from Acanthopanax senticosus with protein tyrosine phosphatase 1B inhibitory activity

Jia-Lin Li et al.

ARCHIVES OF PHARMACAL RESEARCH (2017)

Article Chemistry, Medicinal

Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity

Binh T. D. Trinh et al.

FITOTERAPIA (2017)

Article Agriculture, Multidisciplinary

Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)

Jun Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

Article Plant Sciences

Bioactive alkaloids from the aerial parts of Houttuynia cordata

Qinge Ma et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

Article Medicine, Research & Experimental

Protective potential of Averrhoa bilimbi fruits in ameliorating the hepatic key enzymes in streptozotocin-induced diabetic rats

Surya B. Kurup et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Chemistry, Medicinal

PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation

Jun Li Yang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Medicine, Research & Experimental

Modulatory effects of Caralluma fimbriata extract against high-fat diet induced abnormalities in carbohydrate metabolism in Wistar rats

Gujjala Sudhakara et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Biochemistry & Molecular Biology

Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata

Yan Lin et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2017)

Article Tropical Medicine

Sapium ellipticum (Hochst) Pax ethanol leaf extract modulates glucokinase and glucose-6-phosphatase activities in streptozotocin induced diabetic rats

Osasenaga Macdonald Ighodaro et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2017)

Article Medicine, Research & Experimental

Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway

Dan Tang et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Biochemical Research Methods

Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae)

Anna Pitschmann et al.

PHYTOCHEMICAL ANALYSIS (2016)

Article Biochemistry & Molecular Biology

PTP1B, α-glucosidase, and DPP-IV inhibitory effects for chromene derivatives from the leaves of Smilax china L.

Bing Tian Zhao et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Article Chemistry, Multidisciplinary

Macleayine, a new alkaloid from Macleaya cordata

Chun-Mei Sai et al.

CHINESE CHEMICAL LETTERS (2016)

Article Biochemistry & Molecular Biology

Protein Tyrosine Phosphatase 1B Inhibitors from the Stems of Akebia quinata

Jin-Pyo An et al.

MOLECULES (2016)

Article Plant Sciences

Combretum lanceolatum flowers ethanol extract inhibits hepatic gluconeogenesis: an in vivo mechanism study

Juliany Torres Siqueira et al.

PHARMACEUTICAL BIOLOGY (2016)

Article Plant Sciences

Sesquiterpenoids from the Chinese endangered plant Manglietia aromatica

Li-Jun Wang et al.

PHYTOCHEMISTRY LETTERS (2016)

Article Chemistry, Organic

Macdentichalcone, a unique polycyclic dimeric chalcone from Macaranga denticulata

Chun Lei et al.

TETRAHEDRON LETTERS (2016)

Article Biotechnology & Applied Microbiology

Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential

Dae Hoon Kim et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Tropical Medicine

Potent water extracts of Indonesian medicinal plants against PTP1B

Azis Saifudin et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2016)

Review Biochemistry & Molecular Biology

Regulation of glucose metabolism from a liver-centric perspective

Hye-Sook Han et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2016)

Article Pharmacology & Pharmacy

The potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron

Azis Saifudin et al.

PHARMACOGNOSY RESEARCH (2016)

Article Chemistry, Medicinal

Anti-diabetic and anti-Alzheimer's disease activities of Angelica decursiva

Md. Yousof Ali et al.

ARCHIVES OF PHARMACAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

New Isoprenylated Phenolic Compounds from Morus laevigata

Meng Wang et al.

CHEMISTRY & BIODIVERSITY (2015)

Article Plant Sciences

Novel stilbenes from Artocarpus nanchuanensis

Pu-Zhao Zhang et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2015)

Article Chemistry, Medicinal

Anti-Diabetic Effect of Aster sphathulifolius in C57BL/KsJ-db/db Mice

Xingfu Yin et al.

JOURNAL OF MEDICINAL FOOD (2015)

Review Biochemistry & Molecular Biology

Molecular pathophysiology of hepatic glucose production

Kfir Sharabi et al.

MOLECULAR ASPECTS OF MEDICINE (2015)

Article Biochemistry & Molecular Biology

Protein Tyrosine Phosphatase 1B Inhibitors from the Roots of Cudrania tricuspidata

Tran Hong Quang et al.

MOLECULES (2015)

Article Biochemistry & Molecular Biology

Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.

Lan Jiang et al.

MOLECULES (2015)

Review Cell Biology

Protein-tyrosine phosphatase 1B substrates and metabolic regulation

Jesse Bakke et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2015)

Article Biotechnology & Applied Microbiology

Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice

Jing Sun et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Medicine, General & Internal

Type 2 diabetes mellitus

Ralph A. DeFronzo et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Review Biochemistry & Molecular Biology

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

Simon M. Schultze et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2012)

Review Medical Laboratory Technology

Molecular mechanisms of insulin resistance and associated diseases

Barbara Mlinar et al.

CLINICA CHIMICA ACTA (2007)

Article Biochemistry & Molecular Biology

Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake

Wei Zhang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2006)

Review Endocrinology & Metabolism

Role of the liver in the control of carbohydrate and lipid homeostasis

C Postic et al.

DIABETES & METABOLISM (2004)

Review Multidisciplinary Sciences

Insulin signalling and the regulation of glucose and lipid metabolism

AR Saltiel et al.

NATURE (2001)

Article Biochemistry & Molecular Biology

Elevated expression and activity of protein-tyrosine phosphatase 1B in skeletal muscle of insulin-resistant type II diabetic Goto-Kakizaki rats

SS Dadke et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)

Article Medicine, Research & Experimental

Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle

K Cusi et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)