期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.773848
关键词
HIV; antiretroviral therapy; DHCR7; DBP; SNP; immune reconstitution; CD4(+) T cells
资金
- Instituto de Salud Carlos III [RD16/0025/0013, RD16CIII/0002/0002]
- State Plan for Scientific and Technical Research and Innovation
- Institute of Health Carlos III
- ISCIII - SubDirectorate General for Research Assessment and Promotion
- European Regional Development Fund (ERDF)
- Centro de Investigacion Biomedica en Red (CIBER) de Enfermedades Infecciosas [CB21/13/00044, CB21/13/00020, CB21/13/00063]
- ISCIII [CP17CIII/00007, CPII19/00025]
The study found that DHCR7 rs3829251 and DBP rs7041 gene polymorphisms are associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
Background: The lack of the recovery of CD4(+) T-cells (CD4(+) recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4(+) recovery in naive HIV-infected patients who started ART with low baseline CD4(+).Methods: We conducted a retrospective study in 411 naive individuals with plasma HIV load >200 copies/mL and CD4(+) <200 cells/mm(3). During 24 months of follow-up, all patients had plasma HIV load Results: CD4(+) recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) (p-value < 0.05). DBP rs7041 AA genotype was linked to increase in CD4(+) (adjusted arithmetic mean ratio (aAMR) = 1.22; q-value = 0.011), increase in CD4(+) >= P75th [adjusted odds ratio (aOR) = 2.31; q-value = 0.005], slope of CD4(+) recovery (aAMR = 1.25; q-value = 0.008), slope of CD4(+) recovery >= P75th (aOR = 2.55; q-value = 0.005) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 1.89; q-value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4(+) (aAMR = 1.43; q-value = 0.031), increase in CD4(+) >= P75th (aOR = 3.92; q-value = 0.030), slope of CD4(+) recovery (aAMR = 1.40; q-value = 0.036), slope of CD4(+) recovery >= P75th (aOR = 3.42; q-value = 0.031) and achievement of CD4(+) >= 500 cells/mm(3) (aOR = 5.68; q-value = 0.015).Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4(+) recovery in HIV-infected patients who started cART with low CD4(+) T-cell counts.
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