Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-κB Pathway and NLRP3 Expression

Article Chemistry, Multidisciplinary

Gout-associated monosodium urate crystal-induced necrosis is independent of NLRP3 activity but can be suppressed by combined inhibitors for multiple signaling pathways

Chun-su Zhong et al.

Summary: Monosodium urate (MSU) crystals induce NLRP3-independent necrosis in gout, which can be inhibited by combined inhibitors targeting multiple signaling pathways.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Chemistry, Medicinal

Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study

Jieru Han et al.

Summary: Dioscin exhibits anti-inflammatory effects by suppressing the production of inflammatory cytokines and inhibiting the activation of NLRP3 and TLR4/NF-κB signaling pathway, offering potential as a therapeutic drug for gouty arthritis initiated by monosodium urate crystals.

JOURNAL OF NATURAL MEDICINES (2021)

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Article Plant Sciences

Study on the compatibility effect and active constituents of Atractylodis Rhizoma in Ermiao Wan against Acute Gouty Arthritis

Xiao-Ling Fu et al.

Summary: This study investigated the rationality of the combination of Phellodendri Chinensis Cortex (PC) and Atractylodis Rhizoma (AR) in the classical Chinese medicine prescription Ermiao Wan (EMW) for the treatment of acute gouty arthritis (AGA). The results showed that the combination of PC and AR volatile oil extract was more effective in reducing ankle joint swelling and improving pathological changes compared to other combinations. Additionally, the volatile oil extract of AR was found to enhance the blood exposure level of PC-related alkaloids, affecting the pharmacokinetics of PC and potentially contributing to its enhanced anti-AGA activity.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization

Mi Nam Lee et al.

Summary: The NLRP3 inflammasome is an important component in the pathogenesis of various diseases, and luteolin may potentially suppress NLRP3 activation to combat inflammatory diseases.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Immunology

Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats

Jinhui Dong et al.

Summary: The study revealed that luteolin can ameliorate inflammation and Th1/Th2 imbalance in allergic rhinitis rats by regulating the TLR4/NF-kappa B pathway. This suggests that luteolin could be a potential candidate drug for allergic rhinitis treatment.

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY (2021)

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Article Plant Sciences

Reduning injection and its effective constituent luteoloside protect against sepsis partly via inhibition of HMGB1/TLR4/NF-κB/MAPKs signaling pathways

Zheng Wang et al.

Summary: The study demonstrated that Reduning injection (RDN) and its effective constituent luteoloside showed significant protective effects against sepsis, suggesting they may be potential candidate drugs for sepsis treatment. The mechanism of action partially involved the inhibition of HMGB1/TLR4/NF-kappa B/MAPK signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Food Science & Technology

Antidepressant-like Effects of Degraded Porphyran Isolated from Porphyra haitanensis

Li-Tao Yi et al.

Summary: Degraded porphyran extracted from Porphyra haitanensis has shown potential antidepressant effects by inhibiting neuroinflammation and enhancing neurogenesis in the central nervous system.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

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Article Plant Sciences

Baeckein E suppressed NLRP3 inflammasome activation through inhibiting both the priming and assembly procedure: Implications for gout therapy

Xiaobing Lin et al.

Summary: BF-2 effectively inhibited cell pyroptosis and IL-1 beta secretion in macrophages, as well as NLRP3 inflammasome activation in a gout mouse model. It achieved this by alleviating mitochondrial damage-mediated oxidative stress, inhibiting NLRP3 inflammasome assembly, and blocking the MAPK/NF-kappa B signaling pathways. The findings suggest BF-2 as a potential drug candidate for inflammatory diseases related to NLRP3 inflammasome activation.

PHYTOMEDICINE (2021)

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Article Plant Sciences

Luteolin ameliorates LPS-induced acute liver injury by inhibiting TXNIP-NLRP3 inflammasome in mice

Xiaohui Wang et al.

Summary: Luteolin effectively protects against acute liver injury induced by LPS through inhibiting the TXNIP-NLRP3 axis, thereby reducing NLRP3 inflammasome activation and liver inflammation, as well as alleviating oxidative stress and hepatocyte injury.

PHYTOMEDICINE (2021)

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Article Neurosciences

Thioredoxin interacting protein regulates age-associated neuroinflammation

Saifudeen Ismael et al.

Summary: This study suggests that TXNIP/NLRP3 inflammasome pathway is involved in senile dementia, with TXNIP upregulation in aged animals leading to NLRP3 inflammasome over-activity. Inhibition of TXNIP along with verapamil results in downregulation of TXNIP/NLRP3-inflammasome, improved cognitive and sensorimotor abilities, and potential deceleration of senile dementia.

NEUROBIOLOGY OF DISEASE (2021)

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Article Immunology

Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice

Ji-Xiao Zhu et al.

Summary: Luteolin, luteoloside and apigenin can attenuate hyperuricemia by reducing the production and increasing the excretion of uric acid, mediated by inhibiting inflammatory signaling pathways.

INFLAMMOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis

Chengyu Yin et al.

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Review Rheumatology

Gout: a disease involved with complicated immunoinflammatory responses: a narrative review

Meimei Wu et al.

CLINICAL RHEUMATOLOGY (2020)

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Article Neurosciences

Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series

Valerie Joers et al.

NEUROBIOLOGY OF DISEASE (2020)

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Article Neurosciences

Pregnancy associated epigenetic markers of inflammation predict depression and anxiety symptoms in response to discrimination

Femke Sluiter et al.

NEUROBIOLOGY OF STRESS (2020)

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Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Rheumatology

Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors

Lenka Hasikova et al.

RHEUMATOLOGY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways

Yanan Lv et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2019)

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Article Medicine, General & Internal

Gout

Nicola Dalbeth et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Immunology

Apigenin attenuates acrylonitrile-induced neuro-inflammation in rats: Involved of inactivation of the TLR4/NF-κB signaling pathway

Fenxian Zhao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Immunology

Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation

Kyle Caution et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Immunology

Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPARγ/Nrf2/NF-κB signaling pathway

Qiaoling Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Immunology

Prominent Inflammatory Features of Monocytes/Macrophages in Acute Calcium Pyrophosphate Crystal Arthritis: a Comparison with Acute Gouty Arthritis

Ji Hye Jeong et al.

IMMUNE NETWORK (2019)

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Article Rheumatology

TNF-α potentiates uric acid-induced interleukin-1β (IL-1β) secretion in human neutrophils

Kohei Yokose et al.

MODERN RHEUMATOLOGY (2018)

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Review Agriculture, Multidisciplinary

Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication

Jhih-Jia Jhang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Plant Sciences

Luteolin-4'-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models

Yan Lin et al.

PHYTOMEDICINE (2018)

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Article Rheumatology

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Charles McWherter et al.

ARTHRITIS RESEARCH & THERAPY (2018)

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Review Biochemistry & Molecular Biology

Molecular Pathophysiology of Gout

Jyaysi Desai et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Review Multidisciplinary Sciences

Gout: An old disease in new perspective - A review

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JOURNAL OF ADVANCED RESEARCH (2017)

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Alpha-1-anti-trypsin-Fc fusion protein ameliorates gouty arthritis by reducing release and extracellular processing of IL-1β and by the induction of endogenous IL-1Ra

Leo A. B. Joosten et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice

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Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout

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Monosodium urate crystals trigger Nrf2-and heme oxygenase-1-dependent inflammation in THP-1 cells

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Luteoloside Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Inhibition of NLRP3 Inflammasome

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Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

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Changes in toll-like receptor (TLR)4-NFκB-IL1β signaling in male gout patients might be involved in the pathogenesis of primary gouty arthritis

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NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B4 in a murine model of gout

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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

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Active Flavonoids From Lagotis brachystachya Attenuate Monosodium Urate-Induced Gouty Arthritis via Inhibiting TLR4/MyD88/NF-κB Pathway and NLRP3 Expression

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