4.7 Article

Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver

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Summary: The biological clock controls metabolic functions in almost all organs, with nutrient metabolism, substrate processing, and detoxification in livers being circadian controlled. The clock gene Per1 is specifically elevated in mice exposed to toxins such as carbon tetrachloride, and its deficiency leads to a slowed metabolic rate of toxins and reduced liver injury and fibrosis. PER1 mediates toxin metabolism and could be a therapeutic target for toxin-induced hepatotoxicity.

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