期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.791214
关键词
2,3,5,4'-tetrahydroxystilbene-2-O-beta; -D-glucoside; anti-inflammation; antioxidant; neuroprotection; cardiovascular protection; pharmacological and pharmacokinetic properties; toxicity
资金
- National Natural Science Foundation of China [81891012, 81630101, U19A2010]
- Sichuan Province Science and Technology Program [2021JDRC0041]
- Xinglin Scholar Research Premotion Project of Chengdu University of Traditional Chinese Medicine [CXTD2018019]
This review comprehensively summarizes the pharmacological and pharmacokinetic properties of 2,3,4 & PRIME;,5-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG) isolated from Polygonum multiflorum Thunb. It highlights the significant activities of TSG in treating various diseases and discusses its molecular mechanisms. The toxicity and pharmacokinetics of TSG are also discussed in this review.
Polygonum multiflorum Thunb. (He-shou-wu in Chinese), a Chinese botanical drug with a long history, is widely used to treat a variety of chronic diseases in clinic, and has been given the reputation of rejuvenating and prolonging life in many places. 2,3,4 & PRIME;,5-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG, C20H22O9) is the main and unique active ingredient isolated from Polygonum multiflorum Thunb., which has extensive pharmacological activities. Modern pharmacological studies have confirmed that TSG exhibits significant activities in treating various diseases, including inflammatory diseases, neurodegenerative diseases, cardiovascular diseases, hepatic steatosis, osteoporosis, depression and diabetic nephropathy. Therefore, this review comprehensively summarizes the pharmacological and pharmacokinetic properties of TSG up to 2021 by searching the databases of Web of Science, PubMed, ScienceDirect and CNKI. According to the data, TSG shows remarkable anti-inflammation, antioxidation, neuroprotection, cardiovascular protection, hepatoprotection, anti-osteoporosis, enhancement of memory and anti-aging activities through regulating multiple molecular mechanisms, such as NF-kappa B, AMPK, PI3K-AKT, JNK, ROS-NO, Bcl-2/Bax/Caspase-3, ERK1/2, TGF-beta/Smad, Nrf2, eNOS/NO and SIRT1. In addition, the toxicity and pharmacokinetics of TSG are also discussed in this review, which provided direction and basis for the further development and clinical application of TSG.
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