4.7 Editorial Material

Editorial: Exploration of Natural Product Leads for Multitarget-Based Treatment of Cancer-Computational to Experimental Journey

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Bergenin-A Biologically Active Scaffold: Nanotechnological Perspectives

Reecha Madaan et al.

Summary: Bergenin, a bioactive compound found in various plants, exhibits a wide range of pharmacological activities. It has the potential to be used as a clinically effective therapeutic agent for the treatment of different diseases. Nanotechnological approaches can be employed to improve the bioavailability of bergenin.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

QSCR Analysis of Cytotoxicity of 6-Fluoro-3-(4H-1,2,4-triazol-3-yl)quinolin-4(1H)-ones on Chinese Hamster Ovary Cell Line: Design of REPUBLIC1986

Shikha Joon et al.

Summary: In this study, a QSCR analysis was performed to investigate the cytotoxicity-inducing structural parameters among fluoroquinolone analogues. The results showed a direct proportionality between hydrogen counts and cytotoxicity, and suggested excluding sulfur and nitrogen while reducing crowding of cyclopropyl rings in future analogues.

CURRENT MEDICINAL CHEMISTRY (2022)

Review Pharmacology & Pharmacy

Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease

Rajeev K. Singla et al.

Summary: Parkinson's disease is a common chronic disorder in adults with a complex pathogenesis and limited treatment options. Natural products for symptomatic treatment have shown neuroprotective effects by increasing dopamine levels, managing oxidative stress, and reducing inflammation.

CURRENT DRUG TARGETS (2021)

Article Biochemistry & Molecular Biology

Protein reliability analysis and virtual screening of natural inhibitors for SARS-CoV-2 main protease (Mpro) through docking, molecular mechanic & dynamic, and ADMET profiling

Karina Kapusta et al.

Summary: Due to the lack of specific drugs for the novel coronavirus, scientists are working on finding potential antiviral drugs using computational methods. This study used comparative methods for receptor-based virtual screening and found structures with PDB ID 6LU7, 6Y2G, and 6Y2F to have good reproducibility. The influence of crystallographic water on virtual screening results was also investigated.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Review Cell Biology

Natural Products for the Management of Castration-Resistant Prostate Cancer: Special Focus on Nanoparticles Based Studies

Rajeev K. Singla et al.

Summary: Prostate cancer is the most common cancer among men and its progression to castration-resistant prostate cancer is a major challenge in disease management. Resistance mechanisms include activation of androgen receptors and tumor microenvironment. Natural products show potential against resistance pathways but face limitations in clinical trials due to unfavorable pharmacological properties. Nanoparticle formulations offer promise in overcoming these limitations for effective treatment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Chemistry, Medicinal

Unleashing the Potential of Microbial Natural Products in Drug Discovery: Focusing on Streptomyces as Antimicrobials Goldmine

Himangini Bansal et al.

Summary: The natural product specialized metabolites are crucial for current drug development, and advancements in understanding their biosynthesis and biochemistry are leading to a new era of drug exploration. Synthetic biology is providing the tools needed to unlock the therapeutic potential of natural products, circumventing traditional screening program challenges and enabling the discovery of new molecules with novel functions.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Multifaceted Effects of Lycopene: A Boulevard to the Multitarget-Based Treatment for Cancer

Stefania Marzocco et al.

Summary: Lycopene, a pigment belonging to the group of carotenoids, is a powerful antioxidant that protects human health by inhibiting cancer cell proliferation, delaying cell cycle progression, and reducing cell transformation. Its beneficial properties are demonstrated through various molecular and cellular mechanisms in recent scientific studies.

MOLECULES (2021)

Article Pharmacology & Pharmacy

The anti-cancer potential of crotoxin in estrogen receptor-positive breast cancer: Its effects and mechanism of action

Cristina Ferreira Almeida et al.

Summary: This study investigated the anti-cancer mechanisms of crotoxin in ER+ breast cancer, showing that it inhibits cancer cell growth through cell cycle arrest, pathway inhibition, and apoptosis induction, without affecting normal cells.

TOXICON (2021)

Article Genetics & Heredity

A Ferroptosis-Related Gene Signature Identified as a Novel Prognostic Biomarker for Colon Cancer

Xin Qi et al.

Summary: A novel ferroptosis-related gene signature biomarker was identified for overall survival prediction in colon cancer patients, accurately discriminating high-risk and low-risk patients. The signature was closely associated with pivotal cancer hallmarks and demonstrated powerful predictive ability for distinct clinical subgroups. Furthermore, a nomogram incorporating the signature provided a tool for quantifying outcome risk for individual patients.

FRONTIERS IN GENETICS (2021)

Article Biotechnology & Applied Microbiology

Impacts of biomedical hashtag-based Twitter campaign: #DHPSP utilization for promotion of open innovation in digital health, patient safety, and personalized medicine

Maria Kletecka-Pulker et al.

Summary: The study demonstrates that the Twitter campaign centered on #DHPSP was successful in increasing visibility and engaging a large number of users interested in the DHPSP initiative, leading to new scientific collaborations.

CURRENT RESEARCH IN BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Isolation, Docking and In Silico ADME-T Studies of Acacianol: Novel Antibacterial Isoflavone Analogue Isolated from Acacia leucophloea Bark

Rajeev K. Singla et al.

Summary: The research showed that the crude methanolic extracts of Acacia leucophloea stem bark exhibited antimicrobial activity against all tested bacterial strains, albeit weak or moderate. A novel isoflavone analog, named acacianol, was identified in the study with a strong binding affinity towards bacterial DNA gyrase. In silico studies indicated no predicted toxicities except for skin sensitization and chromosome damage.

CURRENT DRUG METABOLISM (2021)

Review Biochemistry & Molecular Biology

Natural Products: Potential Source of DPP-IV Inhibitors

Rajeev K. Singla et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2019)

Article Biochemistry & Molecular Biology

Crotoxin, a neurotoxin from Crotalus durissus terrificus snake venom, as a potential tool against thrombosis development

Camila M. de Andrade et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Review Cell Biology

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

Benedict C. Albensi

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Chemistry, Medicinal

Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens

Rajeev K. Singla et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

NF-kappa B signaling in inflammation

Ting Liu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2017)

Review Chemistry, Medicinal

Recent Advancement in Natural Hyaluronidase Inhibitors

Luciana Scotti et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)