期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.767975
关键词
glucosinolates; isothiocyanates; cardiometabolic disorders; neurological disorders; musculoskeletal health; cancer; cruciferous vegetables
资金
- National Health and Medical Research Council of Australia Emerging Leadership Investigator Grant [1172987]
- National Heart Foundation of Australia Post-Doctoral Research Fellowship [102498]
- Australian Government Research Training Program Scholarship at Edith Cowan University - Alfred Deakin Postdoctoral Research Fellowship
- Multiple Sclerosis Research Australia
- Royal Perth Hospital Research Foundation Career Advancement Fellowship [00/2020]
- Big C Scientific/Clinical Research Grant [11-13R]
- National Heart Foundation of Australia Future Leader Fellowship [102817]
- National Health and Medical Research Council of Australia Senior Research Fellowship [1116973]
Research suggests that a diet rich in fruits and vegetables can delay and prevent the onset of chronic diseases, particularly certain cancers. Glucosinolates in cruciferous vegetables have anti-inflammatory, antioxidant, and chemo-protective effects.
An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.
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