期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.782457
关键词
sleep disturbances; ketamine; antidepressant; depression; neurocognition
资金
- Joint plan of key R&D plan of Liaoning Provincial Science and Technology Department [2020JH2/10300123]
- 345 Talent project
- Support Plan for Innovative Talents in Liaoning Higher Education Institution [201834]
Sleep is crucial for health and longevity, with disturbances potentially leading to various physical and psychological disorders. Ketamine, originally used as an antidepressant, has shown new potential applications in treating sleep disturbances and circadian rhythm disorders, in addition to its well-known anesthetic and analgesic properties.
Recently, sleep has been recognized as a crucial factor for health and longevity. The daily sleep/wake cycle provides the basis of biorhythm, which controls whole-body homeostasis and homeodynamics. Sleep disturbances can contribute to several physical and psychological disorders, including cardiovascular disease, obesity, depression, and cognitive dysfunction. The clinical use of the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine began in the 1970s. Over the years, physicians have used it as a short-acting anesthetic, analgesic, and antidepressant; however, in-depth research has revealed new possible applications for ketamine, such as for treating sleep disturbances and circadian rhythm disorders. The aim of this narrative review is to examine the literature on the mechanistic role of the antidepressant ketamine in affecting sleep disturbance. Additionally, we discuss the pharmacologic and pharmacokinetic mechanisms of ketamine as an antidepressant and the predictive biomarkers for ketamine's effect on sleep and cognitive function.
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