4.7 Article

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Dermatology

Inhibiting Protein Kinase Activity of Pyruvate Kinase M2 by SIRT2 Deacetylase Attenuates Psoriasis

Lihua Hao et al.

Summary: The study demonstrates that SIRT2-mediated deacetylation of PKM2 directly interacts with PKM2 and suppresses STAT3 phosphorylation, affecting the pathogenesis of psoriasis. Removal of Sirt2 exacerbates skin inflammation in psoriasis, while re-expression of Sirt2 or pharmacological blockade of PKM2 alleviates the disease severity.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Biochemistry & Molecular Biology

2′-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice

Lihua Hao et al.

Summary: The study found that an active compound derived from cinnamon bark could reduce skin inflammation in mice, alleviating the symptoms of psoriasis with no detectable ill effects. The compound blocked an enzyme that activates immune responses in the skin, leading to fewer proinflammatory T cells and controlled epidermal cell growth. This natural product shows potential in treating psoriasis and related inflammatory disorders safely.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

Review Dermatology

Pathogenesis of psoriasis and development of treatment

Eisaku Ogawa et al.

JOURNAL OF DERMATOLOGY (2018)

Editorial Material Dermatology

Research Techniques Made Simple: Murine Models of Human Psoriasis

Jason E. Hawkes et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Editorial Material Pharmacology & Pharmacy

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Michael J. Curtis et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Article Clinical Neurology

Systemic inflammation in asocial BTBR T+ tf/J mice predisposes them to increased psoriatic inflammation

Ahmed Nadeem et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

Review Immunology

The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis

Cristina Albanesi et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Dermatology

Recent Highlights in Psoriasis Research

Samuel T. Hwang et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Review Oncology

PKM2 in carcinogenesis and oncotherapy

Xia He et al.

ONCOTARGET (2017)

Article Genetics & Heredity

Imiquimod has strain-dependent effects in mice and does not uniquely model human psoriasis

William R. Swindell et al.

GENOME MEDICINE (2017)

Review Immunology

Immunology of Psoriasis

Michelle A. Lowes et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

Article Cardiac & Cardiovascular Systems

Role of Kir6.2 subunits of ATP-sensitive potassium channels in endotoxemia-induced cardiac dysfunction

Zhong-Wei Yang et al.

CARDIOVASCULAR DIABETOLOGY (2013)

Article Immunology

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

Barry Flutter et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2013)

Review Dermatology

The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings

David A. Martin et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

Article Plant Sciences

Pharmacological Properties of Shikonin - A Review of Literature since 2002

Isabel Andujar et al.

PLANTA MEDICA (2013)

Article Biochemistry & Molecular Biology

Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

Xueliang Gao et al.

MOLECULAR CELL (2012)

Article Biochemistry & Molecular Biology

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Dimitrios Anastasiou et al.

NATURE CHEMICAL BIOLOGY (2012)

Review Cell Biology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

Editorial Material Radiology, Nuclear Medicine & Medical Imaging

Incidental Finding of F-18 FDG Skin Uptake in a Patient With Psoriasis During the Evaluation of a Recurrent Papillary Thyroid Carcinoma

Claire Bruna-Muraille et al.

CLINICAL NUCLEAR MEDICINE (2011)

Article Multidisciplinary Sciences

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

Weiwei Yang et al.

NATURE (2011)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Article Dermatology

Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells

Michelle A. Lowes et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)

Article Multidisciplinary Sciences

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk et al.

NATURE (2008)

Article Dermatology

The mitogen-activated protein kinases p38 and ERK1/2 are increased in lesional psoriatic skin

C Johansen et al.

BRITISH JOURNAL OF DERMATOLOGY (2005)

Article Biochemical Research Methods

affy -: analysis of Affymetrix GeneChip data at the probe level

L Gautier et al.

BIOINFORMATICS (2004)