期刊
FRONTIERS IN PHARMACOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.829796
关键词
mesoporous silica; MSN; cancer; targeted drug delivery; gene delivery; biodistribution
资金
- Science and Technology Program of Guangzhou, China [202103000089]
- Guangdong Demonstration base for Joint Cultivation of Postgraduates
- Science Foundation for Distinguished Young Scholars of Guangdong [2020B1515020026]
The preparation of mesoporous silica nanocarriers (MSN) has a wide range of medical applications. Different types of MSNs have been developed for various applications, especially in tumor treatment and biomedical imaging. MSNs have shown promise in improving drug therapeutics, introducing new drug delivery strategies, and addressing the limitations of traditional drugs. It is important to both innovate MSNs and understand their biological distribution in order to further develop their potential clinical applications.
Mesoporous silica nanocarrier (MSN) preparations have a wide range of medical applications. Studying the biocompatibility of MSN is an important part of clinical transformation. Scientists have developed different types of mesoporous silica nanocarriers (MSNs) for different applications to realize the great potential of MSNs in the field of biomedicine, especially in tumor treatment. MSNs have achieved good results in diagnostic bioimaging, tissue engineering, cancer treatment, vaccine development, biomaterial application and diagnostics. MSNs can improve the therapeutic efficiency of drugs, introduce new drug delivery strategies, and provide advantages that traditional drugs lack. It is necessary not only to innovate MSNs but also to comprehensively understand their biological distribution. In this review, we summarize the various medical uses of MSN preparations and explore the factors that affect their distribution and biocompatibility in the body based on metabolism. Designing more reasonable therapeutic nanomedicine is an important task for the further development of the potential clinical applications of MSNs.
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