4.5 Article

The Hallucinogenic Serotonin2A Receptor Agonist, 2,5-Dimethoxy-4-Iodoamphetamine, Promotes cAMP Response Element Binding Protein-Dependent Gene Expression of Specific Plasticity-Associated Genes in the Rodent Neocortex

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Lysergic acid diethylamide induces increased signalling entropy in rats' prefrontal cortex

Aurora Savino et al.

Summary: Psychedelic drugs are being considered as potential new compounds for treating psychiatric diseases, with studies showing an impact on neuroplasticity gene expression and the restructuring of gene co-expression networks. This rewiring is associated with an increase in signaling entropy, reflecting the complexity of highly plastic systems, and may shed light on the underlying mechanisms of higher-order phenomena.

JOURNAL OF NEUROCHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Molecular insights into psychedelic drug action

Samuel T. Slocum et al.

Summary: A confluence of factors has reignited interest in psychedelic drugs, with the FDA designating psilocybin as a Breakthrough Therapy for treatment-resistant depression. The clearer understanding of how these drugs exert their effects at the molecular level is essential for further development of applications in hallucinogenic and therapeutic mechanisms.

JOURNAL OF NEUROCHEMISTRY (2022)

Review Psychiatry

How do serotonergic psychedelics treat depression: The potential role of neuroplasticity

Hewa Artin et al.

Summary: Depression is a common mental disorder that often takes time to treat, leading to the development of novel antidepressants such as ketamine and serotonergic psychedelics. While these new drugs show promising results, their mechanisms of action remain poorly understood.

WORLD JOURNAL OF PSYCHIATRY (2021)

Article Neurosciences

Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine

Danilo De Gregorio et al.

Summary: A resurgence of interest in hallucinogens for the treatment of psychiatric disorders has emerged, with studies confirming the efficacy of ketamine in treating depression. Emerging evidence also suggests potential therapeutic properties of psilocybin, LSD, and MDMA for mental diseases.

JOURNAL OF NEUROSCIENCE (2021)

Review Neurosciences

A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

Neil K. Savalia et al.

Summary: Studies have shown that serotonergic psychedelics like psilocybin and ketamine may relieve depression by promoting neural plasticity. Despite targeting distinct molecular receptors in the brain, the behavioral and neural effects of these compounds are similar, possibly by enhancing and suppressing membrane excitability at dendrites.

TRENDS IN NEUROSCIENCES (2021)

Review Psychiatry

Psychedelics and Other Psychoplastogens for Treating Mental Illness

Maxemiliano V. Vargas et al.

Summary: Psychedelics offer new hope for treating brain disorders due to their sustained therapeutic effects and broad potential, but face challenges in clinical scalability. Research on psychoplastogens provides insight into neural plasticity and offers a new paradigm for addressing the underlying pathophysiology of mental illness. Effectively deploying psychoplastogenic medicines at scale will be a key consideration for future development in the field.

FRONTIERS IN PSYCHIATRY (2021)

Article Neurosciences

Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

Ling-Xiao Shao et al.

Summary: The study showed that psilocybin can induce rapid and lasting synaptic rewiring in the cortex, increasing spine size and density. This structural change may have potential implications for long-term integration of experiences and lasting beneficial actions.

NEURON (2021)

Review Psychiatry

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

Cato M. H. de Vos et al.

Summary: Clinical studies suggest that psychedelics induce rapid changes in neuroplasticity mechanisms, leading to alterations in gene and protein expression, increased neurotrophic factor levels, and enhanced dendritic complexity. Repeated administration of psychedelics can directly stimulate neurogenesis and elevate BDNF mRNA levels, indicating potential long-lasting effects on brain plasticity. Future research could focus on deciphering specific cellular mechanisms activated by different psychedelics to better understand their therapeutic potential.

FRONTIERS IN PSYCHIATRY (2021)

Article Chemistry, Medicinal

Transient Stimulation with Psychoplastogens Is Sufficient to Initiate Neuronal Growth

Calvin Ly et al.

Summary: Cortical neuron atrophy is a hallmark of depression, and psychoplastogens like ketamine and LSD have been shown to promote sustained growth of cortical neurons after short periods of stimulation. These psychoplastogens induce cortical neuron growth through distinct phases, with early TrkB activation and later sustained mTOR and AMPA receptor activation being crucial. It is suggested that rapidly excreted psychoplastogens may have unique advantages as neurotherapeutics compared to compounds like ketamine and LSD.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

Article Clinical Neurology

Transcriptional regulation in the rat prefrontal cortex and hippocampus after a single administration of psilocybin

Oskar Hougaard Jefsen et al.

Summary: The study demonstrates that psilocybin rapidly induces gene expression related to neuroplasticity, biased towards the prefrontal cortex, compared to the hippocampus. This provides further evidence for the rapid plasticity-promoting effects of psilocybin.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

Editorial Material Biochemistry & Molecular Biology

Psychedelic Psychiatry's Brave New World

David Nutt et al.

Article Biochemistry & Molecular Biology

Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT2A receptor

Antara A. Banerjee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Neurosciences

Central 5-HT receptors and their function; present and future

Trevor Sharp et al.

NEUROPHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1α axis

Sashaina E. Fanibunda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

Psychedelics Promote Structural and Functional Neural Plasticity

Calvin Ly et al.

CELL REPORTS (2018)

Review Behavioral Sciences

The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders

Florian Duclot et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2017)

Article Neurosciences

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers

Jae-Yeol Joo et al.

NATURE NEUROSCIENCE (2016)

Review Neurosciences

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

Keiichiro Minatohara et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2016)

Review Pharmacology & Pharmacy

Structure and function of serotonin G protein-coupled receptors

John D. McCorvy et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Behavioral Sciences

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects

Ainhoa Bilbao et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2014)

Article Clinical Neurology

Induction of the plasticity-associated immediate early gene Arc by stress and hallucinogens: role of brain-derived neurotrophic factor

Madhurima Benekareddy et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Review Biochemistry & Molecular Biology

CREB: a multifaceted regulator of neuronal plasticity and protection

Kensuke Sakamoto et al.

JOURNAL OF NEUROCHEMISTRY (2011)

Article Neurosciences

New views of Arc, a master regulator of synaptic plasticity

Jason D. Shepherd et al.

NATURE NEUROSCIENCE (2011)

Review Cell Biology

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

Judith Y. Altarejos et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Review Psychiatry

Linking Molecules to Mood: New Insight Into the Biology of Depression

Vaishnav Krishnan et al.

AMERICAN JOURNAL OF PSYCHIATRY (2010)

Article Neurosciences

Enhanced Function of Prefrontal Serotonin 5-HT2 Receptors in a Rat Model of Psychiatric Vulnerability

Madhurima Benekareddy et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Psychiatry

Changes in CREB Phosphorylation and BDNF Plasma Levels during Psychotherapy of Depression

Jakob M. Koch et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2009)

Review Neurosciences

Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system

Steven W. Flavell et al.

ANNUAL REVIEW OF NEUROSCIENCE (2008)

Article Neurosciences

The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function

Clive R. Bramham et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

The molecular neurobiology of depression

Vaishnav Krishnan et al.

NATURE (2008)

Article Biochemical Research Methods

Analyzing real-time PCR data by the comparative C-T method

Thomas D. Schmittgen et al.

NATURE PROTOCOLS (2008)

Article Multidisciplinary Sciences

Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo

Cullen L. Schmid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice

Noelia V. Weisstaub et al.

SCIENCE (2006)

Review Neurosciences

The many faces of CREB

WA Carlezon et al.

TRENDS IN NEUROSCIENCES (2005)

Review Cell Biology

Transcriptional regulation by the phosphorylation-dependent factor CREB

B Mayr et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)

Article Multidisciplinary Sciences

Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway

GY Wu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)