期刊
CANCER MEDICINE
卷 10, 期 24, 页码 8725-8740出版社
WILEY
DOI: 10.1002/cam4.4398
关键词
biomarker; cancer stem cell; circular RNA; colorectal cancer; recurrence and metastasis; therapeutic target
类别
Circular RNAs, a special type of noncoding RNA, exhibit high stability and potential gene regulation effects, playing roles in various biological functions and showing associations with the development and chemotherapy resistance of CRC.
Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are covalently closed circular structures, which have no 5' cap structure and 3' polyA tail and are not affected by RNA exonuclease and actinomycin D. Biological functions Notably, circular RNAs have a high degree of stability and potential effect on gene regulation. Meanwhile, circular RNAs are involved in the sponge action of microRNAs and mediate protein translation and direct binding, alternative splicing, and histone modification. Relationships with CRC Studies have shown that circular RNAs are related to the proliferation, invasion, recurrence, metastasis, ferroptosis, apoptosis, and chemotherapy resistance of CRC. Conclusions This article provides a brief review based on the source, structural characteristics, mechanisms, biological functions of circular RNAs, and the relationships between CRC.
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