Relationship between PPAR-gamma gene polymorphisms and ischemic stroke risk: A meta-analysis

Background: cPublished researches have suggested some associations between PPAR-gamma and ischemic stroke (IS) development. This meta-analysis was conducted to evaluate the association between PPAR-gamma gene polymorphisms and IS risk. Materials and methods: A systematic search was conducted in PubMed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases. The pooled association of odd ratios (ORs) and its 95% confidence interval (CI) was calculated to assess the IS risk of PPAR-gamma rs1801282 C/G and rs3856806 C/T polymorphisms. Furthermore, the heterogeneity test, cumulative analyses, sensitivity analyses, and publication bias were conducted. Result: Sixteen publications with 3786 cases and 5343 controls were identified. Overall findings indicated that rs1801282 C/G polymorphism may be associated with an increased risk for IS (GG vs. CC: OR = 2.17 95%CI = 1.09-4.35, p = .03, I-2 = 0%; GG vs. CC+CG: OR = 2.15, 95%CI = 1.07-4.32, p = .03, I-2 = 0%). The similar results were also found in the subgroup analysis. In addition, no significant association was observed between rs3856806 C/T polymorphism and IS risk. Conclusion: In conclusion, our study showed that PPAR-gamma rs1801282 C/G polymorphism probably plays an important role in IS occurrence. The result should be verified with more studies in the future.

Automated summary

This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.