4.4 Review

Skin microbiome of atopic dermatitis

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Article Allergy

Biofilm propensity ofStaphylococcus aureusskin isolates is associated with increased atopic dermatitis severity and barrier dysfunction in the MPAACH pediatric cohort

Tammy Gonzalez et al.

Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.

ALLERGY (2021)

Article Dermatology

What Have We Learned from GWAS for Atopic Dermatitis?

Sara J. Brown

Summary: GWAS have identified multiple loci associated with atopic dermatitis, confirming existing knowledge and providing new insights, with most risk loci located in intergenic regions with unknown functional mechanisms. Further research is needed to fully understand individual risk.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Article Allergy

Atopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity

Angeline S. L. Tay et al.

Summary: Different microbial profiles on AD skin were identified, with dermotype B showing reduced microbial richness, depletion of certain species, individual-specific outlier abundance of Staphylococcus species, and enrichment in metabolic pathways and virulence genes. These microbial configurations were associated with more severe itching, frequent flares, and increased disease severity in patients.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Virology

Staphylococcal Phage in Combination with Staphylococcus epidermidis as a Potential Treatment for Staphylococcus aureus-Associated Atopic Dermatitis and Suppressor of Phage-Resistant Mutants

Yuzuki Shimamori et al.

Summary: Atopic dermatitis is often associated with the overgrowth of Staphylococcus aureus, and phage therapy shows promising clinical applications in treating skin infections by reducing the bacterial load and disease exacerbation. Typical commensal bacteria in healthy skin can also help reduce S. aureus resistance to phage therapy.

VIRUSES-BASEL (2021)

Review Immunology

Cutaneous Malassezia: Commensal, Pathogen, or Protector?

Shree Harsha Vijaya Chandra et al.

Summary: Malassezia, an important component of the skin microbiome, plays multiple roles in health and disease, acting as a commensal, pathogen, and protector in the skin ecosystem. Advancements in understanding Malassezia's interactions with the host and other microbes are leading towards new therapeutic targets and treatment options for skin health.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Microbiology

A mixed community of skin microbiome representatives influences cutaneous processes more than individual members

Kristin H. Loomis et al.

Summary: This study demonstrates that the microbiome on the skin tissue model significantly alters gene expression patterns, affecting genes involved in apoptosis, proliferation, and extracellular matrix regulation, among others. The microbiome treatment influences the thickness of the epidermal layer, reduces the number of actively proliferating cells, and increases filaggrin expression. It shows that a diverse skin microbiome has unique and pronounced effects on the host, more so than individual microbes.

MICROBIOME (2021)

Article Microbiology

Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical Isolates from Patients with Atopic Dermatitis

Yuzuki Shimamori et al.

Summary: A novel bacteriophage SaGU1 was characterized in this study from sewage samples in Japan, showing potential as a phage therapy agent against S. aureus infections. SaGU1 demonstrated heat stability, lytic activity, and a broad host range targeting clinical isolates of S. aureus on the skin of AD patients. It is considered a promising candidate for developing phage therapy to treat AD caused by pathogenic S. aureus.

CURRENT MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial

Teruaki Nakatsuji et al.

Summary: The study found that the commensal bacterium ShA9 isolated from healthy human skin has the ability to kill Staphylococcus aureus and inhibit inflammation. Local application of ShA9 in patients with atopic dermatitis can reduce adverse events associated with AD.

NATURE MEDICINE (2021)

Article Cell Biology

Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation

Yoshihiro Ito et al.

Summary: The research shows that Staphylococcus cohnii can beneficially inhibit skin inflammation, potentially offering a new therapeutic approach for chronic inflammatory skin conditions.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

Microbial exposure during early human development primes fetal immune cells

Archita Mishra et al.

Summary: During the 2nd trimester of gestation, microbial signals were detected in fetal gut, skin, placenta, and lungs, contributing to fetal immune-priming. Live bacterial strains, including Staphylococcus and Lactobacillus, were identified in fetal tissues, activating memory T cells in the fetal mesenteric lymph node.
Article Immunology

Congenital Deficiency of Conventional Dendritic Cells Promotes the Development of Atopic Dermatitis-Like Inflammation

Yotaro Nishikawa et al.

Summary: Atopic dermatitis is a common inflammatory skin disease characterized by immune abnormalities and impaired skin barrier function. The research indicates that the absence of cDCs may exacerbate immune abnormalities, accelerate the colonization of Staphylococcus aureus on the skin, and worsen the symptoms of the disease.

FRONTIERS IN IMMUNOLOGY (2021)

Editorial Material Allergy

The skin microbiome as a clinical biomarker in atopic eczema: Promises, navigation, and pitfalls

Matthias Reiger et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

Viable bacterial colonization is highly limited in the human intestine in utero

E. Rackaityte et al.

NATURE MEDICINE (2020)

Review Biochemical Research Methods

Biotherapeutic Approaches in Atopic Dermatitis

Elizabeth Huiwen Tham et al.

BIOTECHNOLOGY JOURNAL (2020)

Article Medicine, General & Internal

Atopic dermatitis

Sinéad M Langan et al.

LANCET (2020)

Article Multidisciplinary Sciences

Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE

Rasha Msallam et al.

SCIENCE (2020)

Article Obstetrics & Gynecology

Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection

Maxim D. Seferovic et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2019)

Review Dermatology

Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends

Aleksi J. Hendricks et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2019)

Article Multidisciplinary Sciences

Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors

Katharina Bitschar et al.

NATURE COMMUNICATIONS (2019)

Article Microbiology

The Not-so-Sterile Womb: Evidence That the Human Fetus Is Exposed to Bacteria Prior to Birth

Lisa F. Stinson et al.

FRONTIERS IN MICROBIOLOGY (2019)

Article Microbiology

Staphylococcus aureus Internalized by Skin Keratinocytes Evade Antibiotic Killing

Arwa Al Kindi et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Microbiology

Recoding the metagenome: microbiome engineering in situ

Travis Whitfill et al.

CURRENT OPINION IN MICROBIOLOGY (2019)

Article Allergy

The microbiome in patients with atopic dermatitis

Amy S. Paller et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Allergy

Atopic dermatitis endotypes and implications for targeted therapeutics

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Allergy

Dilute bleach baths used for treatment of atopic dermatitis are not antimicrobial in vitro

Yu Sawada et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Dermatology

Changes in Lesional and Non-lesional Skin Microbiome During Treatment of Atopic Dermatitis

Sunyoung Kwon et al.

ACTA DERMATO-VENEREOLOGICA (2019)

Article Dermatology

Patients with Atopic Dermatitis Colonized with Staphylococcus aureus Have a Distinct Phenotype and Endotype

Eric L. Simpson et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2018)

Review Microbiology

The human skin microbiome

Allyson L. Byrd et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Article Medicine, Research & Experimental

First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis

Ian A. Myles et al.

JCI INSIGHT (2018)

Review Multidisciplinary Sciences

Skin microbiota-host interactions

Y. Erin Chen et al.

NATURE (2018)

Article Immunology

Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides

Martia Zapotoczna et al.

JOURNAL OF INFECTIOUS DISEASES (2017)

Article Dermatology

Skin Colonization by Staphylococcus aureus Precedes the Clinical Diagnosis of Atopic Dermatitis in Infancy

Patrick Meylan et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)

Review Dermatology

Malassezia species in healthy skin and in dermatological conditions

Asja Prohic et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2016)

Article Biochemistry & Molecular Biology

Temporal Stability of the Human Skin Microbiome

Julia Oh et al.

Article Allergy

IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin

Nidhi Malhotra et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Letter Allergy

The skin microbiome is different in pediatric versus adult atopic dermatitis

Baochen Shi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin

Hitokazu Esaki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Dermatology

Diverse Human Skin Fungal Communities in Children Converge in Adulthood

Jay-Hyun Jo et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Article Multidisciplinary Sciences

Human commensals producing a novel antibiotic impair pathogen colonization

Alexander Zipperer et al.

NATURE (2016)

Article Microbiology

Staphylococcus aureus Shifts toward Commensalism in Response to Corynebacterium Species

Matthew M. Ramsey et al.

FRONTIERS IN MICROBIOLOGY (2016)

News Item Microbiology

MICROBIOME Ecology of eczema

Ian D. Odell et al.

NATURE MICROBIOLOGY (2016)

Review Allergy

Genetic and epigenetic studies of atopic dermatitis

Lianghua Bin et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

Transplantation of human skin microbiota in models of atopic dermatitis

Ian A. Myles et al.

JCI INSIGHT (2016)

Article Multidisciplinary Sciences

Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

Ling-juan Zhang et al.

SCIENCE (2015)

Review Microbiology

Staphylococcus aureus toxins

Michael Otto

CURRENT OPINION IN MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Biogeography and individuality shape function in the human skin metagenome

Julia Oh et al.

NATURE (2014)

Article Dermatology

The Presence and Impact of Biofilm-Producing Staphylococci in Atopic Dermatitis

Herbert B. Allen et al.

JAMA DERMATOLOGY (2014)

Review Microbiology

Phenol-soluble modulins - critical determinants of staphylococcal virulence

Gordon Y. C. Cheung et al.

FEMS MICROBIOLOGY REVIEWS (2014)

Review Microbiology

Neutrophils Versus Staphylococcus aureus: A Biological Tug of War

Andras N. Spaan et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 67 (2013)

Article Biochemistry & Molecular Biology

The altered landscape of the human skin microbiome in patients with primary immunodeficiencies

Julia Oh et al.

GENOME RESEARCH (2013)

Article Allergy

Fungal protein MGL_1304 in sweat is an allergen for atopic dermatitis patients

Takaaki Hiragun et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Allergy

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis

Mayte Suarez-Farinas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

Article Multidisciplinary Sciences

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells

Yuumi Nakamura et al.

NATURE (2013)

Article Multidisciplinary Sciences

Topographic diversity of fungal and bacterial communities in human skin

Keisha Findley et al.

NATURE (2013)

Article Dermatology

Diversity of the Human Skin Microbiome Early in Life

Kimberly A. Capone et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)

Review Microbiology

The skin microbiome

Elizabeth A. Grice et al.

NATURE REVIEWS MICROBIOLOGY (2011)

Review Immunology

Immunity against Staphylococcus aureus cutaneous infections

Lloyd S. Miller et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Allergy

Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus

Helen Miajlovic et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Article Medicine, Research & Experimental

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice

John S. Cho et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Article Multidisciplinary Sciences

Topographical and Temporal Diversity of the Human Skin Microbiome

Elizabeth A. Grice et al.

SCIENCE (2009)

Article Allergy

Cytokine modulation of atopic dermatitis filaggrin skin expression

Michael D. Howell et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

The complete genome sequence of Propionibacterium acnes, a commensal of human skin

H Brüggemann et al.

SCIENCE (2004)

Review Biochemistry & Molecular Biology

Autoinduction and signal transduction in the regulation of staphylococcal virulence

RP Novick

MOLECULAR MICROBIOLOGY (2003)