4.5 Review

Nanomaterials-Mediated Structural and Physiological Modulation of Blood Brain Barrier for Therapeutic Purposes

期刊

ADVANCED MATERIALS INTERFACES
卷 9, 期 1, 页码 -

出版社

WILEY
DOI: 10.1002/admi.202101391

关键词

blood brain barrier; brain delivery; nanomaterials; protein corona

资金

  1. National Key Research and Development Program of China [2020YFA0710700]
  2. Innovative Research Groups of the National Natural Science Foundation of China [11621505]
  3. National Natural Science Foundation of China [31971311]
  4. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB36000000]
  5. CAS Interdisciplinary Innovation Team
  6. Bureau of International Cooperation Chinese Academy of Sciences [GJHG1852]
  7. Research and Development Project in Key Areas of Guangdong Province [2019B090917011]

向作者/读者索取更多资源

Nanomaterials, with unique physico-chemical properties such as increased surface area to mass ratio and superior adsorption capacity, are sought after for research in brain delivery of therapeutic substances. Various pathways for nanomaterials to cross BBB have been investigated, including adsorptive-mediated transcytosis, inhibition of active efflux pumps, receptor-mediated transport, and cell-mediated endocytosis.
Blood brain barrier (BBB) protects homeostasis and sensitive environment of brain from several toxic substances coming from the systemic circulation. This barrier along with those substances also prevents therapeutic chemicals to reach brain tissues for several brain diseases. BBB consists of a number of cell types and junctions that help maintain its intricate structure and physiology. To open BBB for therapeutic purposes, researchers are keen to explore the use of nanomaterials as therapeutic agents. Nanomaterials have unique physio-chemical properties such as, increased surface area to mass ratio, superior adsorption capacity, and a wide variety of functionalization possibilities in contrast to bulk materials, making them sought-after for research pertaining to brain delivery of therapeutic substances. Both organic and inorganic nanomaterials have been researched in this regard with numerous interesting functionalizations, and their toxicity and distribution profiles have been well assessed. Different pathways taken up by nanomaterials to cross BBB like adsorptive-mediated transcytosis, inhibition of active efflux pumps, receptor-mediated transport, and cell-mediated endocytosis have also been investigated. This review summarizes the structural and physiological properties and the modulation techniques of BBB for delivery of adsorbed/functionalized nano delivery platforms and imaging nanomaterials across.

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