4.5 Review

Organic Electrochemical Transistors: An Emerging Technology for Biosensing

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Maximilian Moser et al.

Summary: Donor-acceptor polymers based on diketopyrrolopyrrole unit show promising OECT performance similar to all-donor polymers, representing a significant improvement to previously developed D-A copolymers. DFT simulations suggest a positive correlation between hole polaron delocalization and steady-state OECT performance, providing new insights into the design of OECT materials. It is demonstrated that polaron delocalization can be tuned at the molecular level by selecting building blocks in the polymers' conjugated backbone, paving the way for higher performing OECT polymers.

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Xingxing Chen et al.

Summary: Rigid n-type conjugated polymers bearing OEG side chains demonstrated high electron mobility and excellent performance in OECT devices, achieving among the highest levels reported to date. The metal-free aldol-condensation polymerization used for synthesis is beneficial for their application in bioelectronics.

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Marios Sophocleous et al.

Summary: Organic electrochemical transistors (OECTs) have emerged as a major technology in flexible electronics, particularly in the field of biosensors. They have shown great potential in detecting biomolecules, enzymes, bacteria, viruses, cells, nucleotides, as well as in electrophysiological and wearable sensors. The paper reviews the advances in OECT-based biosensors, discusses device physics, and explores future development perspectives.

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Summary: Alzheimer's disease is a neurodegenerative disorder with no specific cure, emphasizing the importance of early diagnosis. A common pathological change in AD-affected brains is the accumulation of Aβ protein into plaques, which was detected using a micron-scale OECT in this study.

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Mixed Conduction in an N-Type Organic Semiconductor in the Absence of Hydrophilic Side-Chains

Jokubas Surgailis et al.

Summary: Organic electrochemical transistors (OECTs) are essential components for biosensors, neuromorphic devices, and complementary circuits. When designing materials for OECTs, including a hydrophilic component is important for ion transport. Research has shown that ladder-type, side-chain free polymer BBL outperforms copolymers like P-90 in OECTs, exhibiting higher ion-to-electron coupling efficiency and mobility, as well as resisting water uptake due to the connectivity of its crystallites.

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Maximilian Moser et al.

Summary: The electrochemically induced volume changes in organic mixed ionic-electronic conductors (OMIECs) have a significant impact on their performance in electronic devices. This study shows that alterations in the molecular structure of OMIECs affect various processes during their electrochemical swelling, requiring careful balancing of these phenomena to maximize device performance. The findings provide insights into the importance of understanding the molecular processes in OMIECs for their potential applications.

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PEDOT:PSS organic electrochemical transistors for electrical cell-substrate impedance sensing down to single cells

Felix Hempel et al.

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Katharina Lieberth et al.

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Operation mechanism of organic electrochemical transistors as redox chemical transducers

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