期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 219, 期 -, 页码 251-256出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2016.06.016
关键词
Pacemakers; Implantable cardioverter defibrillators; Remote monitoring; Telemedicine; Atrial fibrillation; Stroke
Background: Remote Monitoring (RM) of cardiac implantable electronic devices (CIEDs) is recommended in management of Atrial Fibrillation (AF), which is a recognized risk factor for thromboembolism. We tried to elucidate whether stroke incidence observed in a large, remotely monitored population was consistent with the CHA(2)DS(2)VASc risk profile. Methods: Data from 1650 patients [76% male, age 72 (63-68), CHA(2)DS(2)VASc score 3.0 (2.0-4.0)] enrolled during the HomeGuide study and monitored with a daily-transmission RM system providing automatic alerts for AF, were analysed. Of those, 25% had a pacemaker and 75% an implantable cardioverter defibrillator with or without cardiac resynchronization. Estimations of the expected thromboembolic events were based on the population CHA(2)DS(2)VASc score profile used in a computer-simulated Markov model. Results: Eight thromboembolic events were observed with a 4-year cumulative stroke rate of 0.8% (confidence interval, 0.4%-1.5%). Simulations returned from 18.7 to 17.1 expected events, depending on the AF duration assumed to trigger anticoagulation (one-sample log-rank p < 0.03). During the study period, 681 (84%) AF episodes and 129 (16%) atrial tachycardias were detected in 291 patients (18%): 93% of episodes were detected remotely in 269 patients, 66% ofwhomhad no history of AF. Medical interventions were necessary in 305 episodes, 85% of which were detected remotely. Reaction time was 1 (0-6) days for remotely-detected episodes and 33 (14-121) days for episodes detected in clinic (p < 0.0001). Conclusions: In a large CIED population followed remotely for up to 4 years, the incidence of thromboembolic events was less than half the estimations based on the CHA(2)DS(2)VASc risk profile. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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