期刊
NUCLEUS
卷 13, 期 1, 页码 74-78出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19491034.2022.2034269
关键词
Cellular senescence; CTCF; pericentromeric RNA; senescence-associated secretory phenotype; small extracellular vesicles
类别
资金
- Japan Agency of Medical Research and Development [19gm6110023h0001]
- Japan Science and Technology Agency-Moonshot RD [JPMJPS2022]
- Japan Society for the Promotion of Science [20K16344]
- JSPS [19J00796]
- Grants-in-Aid for Scientific Research [20K16344, 19J00796] Funding Source: KAKEN
Cellular senescence leads to significant changes in chromatin organization and gene expression profile, contributing to age-related pathologies and potentially promoting malignant transformation through the senescence-associated secretory phenotype (SASP).
Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP). Chromatin organization and global gene expression are maintained through the CCCTC-binding factor (CTCF). However, the molecular mechanism underlying CTCF regulation and its association with SASP gene expression remains to be fully elucidated. A recent study by our team showed that noncoding RNA (ncRNA) derived from normally silenced pericentromeric repetitive sequences directly impair the DNA binding of CTCF. This CTCF disturbance increases the accessibility of chromatin at the loci of SASP genes and caused the transcription of inflammatory factors. This mechanism may promote malignant transformation.
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