期刊
NANO ENERGY
卷 89, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nanoen.2021.106444
关键词
Poly(l-lactic acid); Electrospinning; Piezoelectricity; Self-powered; Stemcells
类别
资金
- Creative Materials Discovery Program through the National Research Foundation of Korea - Ministry of Science and ICT [2018M3D1A1057844]
- National Science Foundation [CBET-1805975]
The study systematically dissected the effects of dimensional control and heat treatment on the piezoelectric performance of electrospun PLLA nanofibers. Modulation of piezoelectric properties in PLLA nanofibers was critical in determining the differentiation efficiency of stem cells. The findings highlight the potential of electrospun PLLA nanofibers with precisely controlled piezoelectric properties for self-powered stem cell engineering platforms specific to target tissues.
There is an increasing effort to utilize piezoelectric materials as a self-powered platform to electrically stimulate cells/tissues in regenerative medicine and tissue engineering applications. Poly(L-lactic acid) (PLLA) holds great potential for biological applications due to its biodegradability, especially in a nanofibrous form prepared by electrospinning. However, the mechanism underlying its realization and transformation of piezoelectricity is not well understood. In this study, a design-of-experiment approach was employed to systematically dissect the effects of dimensional control and heat treatment on the piezoelectric performance of electrospun PLLA nanofibers. Specifically, we revealed that the fiber diameter- and heat treatment-dependent phase content change between electrospinning-induced amorphous and crystalline alpha/alpha' phases was responsible for the piezoelectric performance in the transverse and longitudinal directions. Such modulation of piezoelectric properties in PLLA nanofibers was critical in determining the differentiation efficiency of stem cells in a phenotype-specific manner, where neurogenesis and osteogenesis were enhanced by orthogonal and shear piezoelectricity, respectively. Overall, our findings highlight the potential of electrospun PLLA nanofibers with precisely controlled piezoelectric properties through a systematic approach for self-powered stem cell engineering platforms, specific to target tissues.
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