期刊
NANO ENERGY
卷 89, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nanoen.2021.106473
关键词
Polyhydroxybutyrate; Reduced graphene oxide; Scaffolds; Surface potential; Piezoelectric response; Modeling
类别
资金
- Tomsk Polytechnic University
- Special Research Fund (BOF) of Ghent University [BOF16/FJD/029, 01IO3618, BAS094-18, BOF14/IOP/003]
- Research Foundation Flanders (FWO) , Belgium [G043219, I002620N]
- Russia Federation
- Russian President's grant [MK-330.2020.8]
- Russian Science Foundation [20-63-47096]
- Ministry of Science and Higher Education [075-15-2021-588]
- national funds through the Portuguese Foundation for Science and Technology/MCTE [UIDB/50011/2020, UIDP/50011/2020]
- national funds (OE) through FCT - Fundacao para a Ciencia e a Tecnologia, I.P. [4, 5, 6, Law 57/2016]
- Hercules Foundation
- Flemish Government (department EWI)
- UAntwerp, Belgium
- Alexander von Humboldt Foundation
- Russian Science Foundation [20-63-47096] Funding Source: Russian Science Foundation
Piezoelectricity is considered essential for bone tissue regeneration, but achieving biocompatibility, biodegradability, and 3D structure with significant piezoresponse remains a challenge. By developing hybrid biocompatible 3D scaffolds with PHB and rGO, researchers successfully enhanced piezoresponse. Optimal piezoresponse was observed at 0.7 wt% rGO, with further increases in rGO content leading to reduced effectiveness.
Piezoelectricity is considered to be one of the key functionalities in biomaterials to boost bone tissue regeneration, however, integrating biocompatibility, biodegradability and 3D structure with pronounced piezoresponse remains a material challenge. Herein, novel hybrid biocompatible 3D scaffolds based on biodegradable poly(3-hydroxybutyrate) (PHB) and reduced graphene oxide (rGO) flakes have been developed. Nanoscale insights revealed a more homogenous distribution and superior surface potential values of PHB fibers (33 +/- 29 mV) with increasing rGO content up to 1.0 wt% (314 +/- 31 mV). The maximum effective piezoresponse was detected at 0.7 wt% rGO content, demonstrating 2.5 and 1.7 times higher out-of-plane and in-plane values, respectively, than that for pure PHB fibers. The rGO addition led to enhanced zigzag chain formation between paired lamellae in PHB fibers. In contrast, a further increase in rGO content reduced the alpha-crystal size and prevented zigzag chain conformation. A corresponding model explaining structural and molecular changes caused by rGO addition in electrospun PHB fibers is proposed. In addition, finite element analysis revealed a negligible vertical piezoresponse compared to lateral piezoresponse in uniaxially oriented PHB fibers based on alpha-phase (P2(1)2(1)2(1) space group). Thus, the present study demonstrates promising results for the development of biodegradable hybrid 3D scaffolds with an enhanced piezoresponse for various tissue engineering applications.
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